Assessing the Associations of Sodium Intake With Long-Term All-Cause and Cardiovascular Mortality in a Hypertensive Cohort
| Autor: | Pamela Singer, Hillel W. Cohen, Michael H. Alderman |
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| Jazyk: | angličtina |
| Rok vydání: | 2014 |
| Předmět: |
Adult
Male medicine.medical_specialty Sodium chemistry.chemical_element Insulin resistance Internal medicine Epidemiology Internal Medicine Medicine Humans Myocardial infarction Risk factor Adverse effect business.industry Middle Aged medicine.disease Blood pressure Endocrinology chemistry Cohort Hypertension Original Article Female New York City business Follow-Up Studies |
| Popis: | Hypertension affects approximately 30% of all US adults1 and is the leading risk factor for cardiovascular morbidity and mortality.2 Although antihypertensive medication is the mainstay of blood pressure (BP) control, dietary sodium restriction has been widely recommended as a public health measure for both prevention and treatment of hypertension.3 Sodium restriction has been found to lower mean BP,4–6 with a recent Cochrane review indicating an average systolic BP (SBP) reduction of 3.5% in hypertensive patients when sodium intake was reduced by 125 mmol/day.7 At the same time, controversy exists on whether this sodium–BP effect actually translates to cardioprevention because intensive sodium restriction may have adverse effects on insulin resistance, triglycerides, and sympathetic nervous system activation.7,8 Studies directly examining the association between sodium intake and cardiovascular outcomes have produced conflicting results, with some finding a direct association, some showing an inverse or J-shaped curve, and others finding no relation to cardiovascular disease mortality. The lack of a consistent association is highlighted by the recent Institute of Medicine report,9 which concluded that the available data preclude a recommendation to restrict sodium to |
| Databáze: | OpenAIRE |
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