Free thyroxine and 3,3',5'-triiodothyronine levels in cerebrospinal fluid in patients with endogenous depression
| Autor: | Jens Faber, Carsten Kirkegaard |
|---|---|
| Rok vydání: | 1991 |
| Předmět: |
Male
medicine.medical_specialty Triiodothyronine Reverse Endocrinology Diabetes and Metabolism Thyrotropin Hyperthyroidism Endocrinology Cerebrospinal fluid Hypothyroidism Internal medicine Humans Medicine Hyperthyroid patient In patient Electroconvulsive Therapy Thyrotropin-Releasing Hormone Depression (differential diagnoses) Aged Depressive Disorder Triiodothyronine business.industry General Medicine Free thyroxine Middle Aged Pathophysiology Thyroxine Endogenous depression Female business |
| Zdroj: | Acta Endocrinologica. 124:166-172 |
| ISSN: | 1479-683X 0804-4643 |
| DOI: | 10.1530/acta.0.1240166 |
| Popis: | Total and free concentrations of T4 and rT3 in serum and cerebrospinal fluid were estimated by ultrafiltration in 12 patients with unipolar endogenous depression before and after electroconvulsive treatment. Recovery from depression resulted in a decrease in CSF concentrations of free T4 (median) (26.2 to 21.4 pmol/l, p3 (14.1 to 12.3 pmol/l, p4 in the cerebrospinal fluid were lower than those in serum (p3 in the cerebrospinal fluid were considerably higher than those found in serum (p4 and rT3 in the cerebrospinal fluid were similar to those found in patients with endogenous depression, whereas 4 hypothyroid patients and one hyperthyroid patient had considerably lower and higher, respectively, concentrations of both free T4 and rT3. In conclusion, levels of free T4 and free rT3 in the cerebrospinal fluid are increased during depression compared with levels after recovery, probably reflecting an increased supply of T4 from serum and an increased production of rT3 from T4 in the brain. The data also suggest that the transport of iodothyronines between serum and the cerebrospinal fluid is restricted. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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