The case for cortical steroid hormone acceleration of neoglucogenesis from fat in diabetic subjects. A summary of five years' investigative work
| Autor: | Harry E. Balch, Eleanor Kipp, Lenore Boling, Sadie Smyrl, Nancy Bloomfield, George Fukayama, Marjorie Coelho, Sheldon Margen, John W. Partridge, George D. Michaels, June Bilisoly, Florence Olson, Laurance W. Kinsell |
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| Rok vydání: | 1954 |
| Předmět: |
medicine.medical_specialty
Endocrinology Diabetes and Metabolism medicine.medical_treatment Clinical Biochemistry Carbohydrates Carbohydrate metabolism Biochemistry Endocrinology Insulin resistance Adrenal Cortex Hormones Internal medicine Diabetes mellitus medicine Diabetes Mellitus Humans Chemistry Insulin Biochemistry (medical) medicine.disease Lipid Metabolism Lipids Hormones Steroid hormone Gluconeogenesis Pancreatectomy Carbohydrate Metabolism Hormone |
| Zdroj: | The Journal of clinical endocrinology and metabolism. 14(2) |
| ISSN: | 0021-972X |
| Popis: | PRODUCTION or accentuation of the diabetic state by adrenocorticotropin and by cortical steroids is well documented (1). In association with the diabetogenic effect of these hormones, one also observes a progressive degree of insulin resistance. The mechanism of these metabolic changes has never been satisfactorily explained. The possible explanations for such effects include the following: 1. Inhibition of insulin production. Since corticotropin and cortical steroids accentuate the diabetes associated with total pancreatectomy, this is obviously an inadequate explanation. 2. Insulin destruction. Unsatisfactory, as in “1”. 3. Blockade of insulin effect, perhaps at the enzymatic level. On the basis of recent findings in our laboratory, this appears probable (2). As in “1” and “2,” however, such an hypothesis fails to explain the total diabetogenic effect of adrenal steroids. |
| Databáze: | OpenAIRE |
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