Toxicity of silver nanoparticles on endometrial receptivity in female mice
| Autor: | Fariborz Keyhanfar, Vahid Pirhajati Mahabadi, Sahar Eghbali, Rajender S. Varma, Marziyeh Ajdary |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Male
Silver Physiology Interleukin-1beta Male mice Metal Nanoparticles Endometrium Silver nanoparticle Andrology Mice Pregnancy Physiology (medical) medicine Animals Embryo Implantation Particle Size Interleukin 6 Pharmacology biology Dose-Response Relationship Drug Chemistry Interleukin-6 General Medicine medicine.disease medicine.anatomical_structure Nmri mice Toxicity biology.protein Female Endometrial receptivity |
| Zdroj: | Canadian journal of physiology and pharmacology. 99(12) |
| ISSN: | 1205-7541 |
| Popis: | Nanoparticles (NPs) have many toxic effects on fertility and can prevent successful implantation by affecting the maternal uterine tissue. Herein, by deploying 30 female NMRI mice, the effect of silver NPs on the endometrium and implantation has been investigated. Using spherical silver NPs of a diameter of 18–30 nm at doses of 2 and 4 mg/kg, mice in two groups were treated. Then, female mice mated with male mice. Endometrial tissue was extracted 4.5 days later. On the fourth day of pregnancy, the mice were anesthetized and blood samples were taken from the heart; furthermore, endometrial tissue was isolated and used for molecular tests, inductively coupled plasma, and examination of pinopods. The results revealed that the levels of interleukin 6 (IL-6) and IL-1β and the accumulation of NPs in endometrial tissue in the group receiving NPs at a dose of 4 mg/kg had a major increase relative to the other two groups (p < 0.05); the group receiving a dose of 4 mg/kg exhibited a decrease in pinopods and microvillus compared with the other two groups. According to the results, NPs can reach the endometrium, suggesting that caution should be exercised due to serious exposure to NPs throughout pregnancy. |
| Databáze: | OpenAIRE |
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