Ethics and regulatory considerations for the clinical translation of somatic cell human epigenetic editing

Autor:	Ruth Chadwick, Nikolajs Zeps, Tamra Lysaght, Poh San Lai, Jeremy Sugarman, Roger Foo, Simona Giordano, Alexandre Erler, G. Owen Schaefer, Wei Leong Chew, Vicki Xafis
Rok vydání:	2021
Předmět:	Epigenomics Gene Editing 0301 basic medicine Forum Somatic cell Translation (biology) Cell Biology Computational biology Epigenome Biology Biochemistry Somatic psychology Variety (cybernetics) Translational Research Biomedical 03 medical and health sciences Germ Cells Phenotype 030104 developmental biology 0302 clinical medicine Genetics Humans Epigenetics 030217 neurology & neurosurgery Developmental Biology
Zdroj:	Stem Cell Reports
ISSN:	2213-6711
DOI:	10.1016/j.stemcr.2021.06.004
Popis:	Altering the human epigenome with gene-editing technology in attempt to treat a variety of diseases and conditions seems scientifically feasible. We explore some of the ethical and regulatory issues related to the clinical translation of human epigenetic editing arguing that such approaches should be considered akin to somatic therapies.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af95f5d4fe672ee07a452498a3a003b8 https://doi.org/10.1016/j.stemcr.2021.06.004 Zobrazit plný text záznamu