Acute ghrelin administration reverses depressive-like behavior induced by bilateral olfactory bulbectomy in mice
| Autor: | Marisa S. Ghersi, Marina Flavia Ponzio, Florencia Buteler, Susana R. de Barioglio, Ana Lúcia S. Rodrigues, Marta Fiol de Cuneo, Valeria P. Carlini, Helgi B. Schiöth, A. C. Martini, Daniele G. Machado |
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| Rok vydání: | 2012 |
| Předmět: |
medicine.medical_specialty
Physiology Growth hormone receptor Biochemistry Mice Cellular and Molecular Neuroscience Endocrinology Animal model Internal medicine medicine Animals Behavior Animal Depression Immobility Response Tonic bacterial infections and mycoses Olfactory Bulb Antidepressive Agents Ghrelin Tail suspension test Olfactory bulb Hindlimb Suspension Antidepressant Female Analysis of variance Psychology hormones hormone substitutes and hormone antagonists Hormone |
| Zdroj: | Peptides. 35:160-165 |
| ISSN: | 0196-9781 |
| Popis: | This study aims to examine the antidepressant-like action of Ghrelin (Ghr), a hormone synthesized predominantly by gastrointestinal endocrine cells and released during periods of negative energy balance, in two behavioral models: tail suspension test (TST), a predictive model of antidepressant activity, and the olfactory bulbectomy (OB), an established animal model of depression. The reduction in the immobility time in the TST was the parameter used to assess antidepressant-like effect of Ghr. The depressive-like behavior in olfactory bulbectomized mice was inferred through the increase in the immobility time in the TST and the hyperlocomotor activity in the open-field test. Ghr produced antidepressant-like effect in TST (0.3 nmol/μl, i.c.v.), and reversed OB-induced depressive-like behavior. In conclusion, these results provide clear evidence that an acute administration of ghrelin produce antidepressant-like effect in the TST and OB. |
| Databáze: | OpenAIRE |
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