Four New Antibacterial Xanthones from the Marine-Derived Actinomycetes Streptomyces caelestis
| Autor: | Ying Xu, Xian-Rong Guo, Yongxin Li, Xixiang Zhang, Zhuang Han, Pok-Yui Lai, Ling-Li Liu, Jia-Liang Zhong, Pei-Yuan Qian, Liang Lu |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
Methicillin-Resistant Staphylococcus aureus
Staphylococcus aureus Stereochemistry Xanthones Streptomyces caelestis citreamicin antibacterial MRSA Pharmaceutical Science Microbial Sensitivity Tests medicine.disease_cause Streptomyces Article Microbiology Minimum inhibitory concentration Drug Discovery medicine lcsh:QH301-705.5 Pharmacology Toxicology and Pharmaceutics (miscellaneous) biology biology.organism_classification Staphylococcus haemolyticus Methicillin-resistant Staphylococcus aureus Anti-Bacterial Agents lcsh:Biology (General) Streptomycin Antibacterial activity Bacillus subtilis medicine.drug |
| Zdroj: | Marine Drugs; Volume 10; Issue 11; Pages: 2571-2583 Marine Drugs Marine Drugs, Vol 10, Iss 11, Pp 2571-2583 (2012) |
| ISSN: | 1660-3397 |
| DOI: | 10.3390/md10112571 |
| Popis: | Four new polycyclic antibiotics, citreamicin θ A (1), citreamicin θ B (2), citreaglycon A (3), and dehydrocitreaglycon A (4), were isolated from marine-derived Streptomyces caelestis. The structures of these compounds were elucidated by 1D and 2D NMR spectra. All four compounds displayed antibacterial activity against Staphylococcus haemolyticus, Staphylococcus aureus, and Bacillus subtillis. Citreamicin θ A (1), citreamicin θ B (2) and citreaglycon A (3) also exhibited low MIC values of 0.25, 0.25, and 8.0 μg/mL, respectively, against methicillin-resistant Staphylococcus aureus (MRSA) ATCC 43300. |
| Databáze: | OpenAIRE |
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