Allelic heterogeneity and trade-off shape natural variation for response to soil micronutrient

Autor: Matthew Andreatta, Seifollah Poormohammad Kiani, Thierry Robert, Olivier Loudet, David E. Salt, Matthieu Simon, Charlotte Trontin
Přispěvatelé: Institut Jean-Pierre Bourgin (IJPB), Institut National de la Recherche Agronomique (INRA)-AgroParisTech, Dept Hort & Landscape Architecture, Purdue University [West Lafayette], Lab Ecol Systemat & Evolut, Université Paris-Sud - Paris 11 (UP11)
Jazyk: angličtina
Rok vydání: 2012
Předmět:
0106 biological sciences
Evolutionary Genetics
Cancer Research
[SDV]Life Sciences [q-bio]
Arabidopsis
DIVERSITY
Population genetics
Plant Genetics
01 natural sciences
Soil
LOCAL ADAPTATION
Natural Selection
Genetics (clinical)
POPULATION
2. Zero hunger
Genetics
0303 health sciences
education.field_of_study
GENETIC-VARIATION
EVOLUTIONARY DYNAMICS
ARABIDOPSIS-THALIANA
POLYMORPHISM
DROSOPHILA
TRAITS
PLANTS
Fixation (population genetics)
Phenotype
Allelic heterogeneity
Research Article
lcsh:QH426-470
Population
Anion Transport Proteins
Biology
Molecular Genetics
03 medical and health sciences
Genetic Heterogeneity
Genetic drift
Genetic variation
education
Molecular Biology
Ecology
Evolution
Behavior and Systematics
Alleles
030304 developmental biology
Molybdenum
Evolutionary Biology
Polymorphism
Genetic
Genetic heterogeneity
Arabidopsis Proteins
Genetic Drift
Genetic Variation
15. Life on land
lcsh:Genetics
Haplotypes
Genetic Polymorphism
Neutral theory of molecular evolution
Population Genetics
010606 plant biology & botany
Zdroj: PLoS Genetics
PLoS Genetics, Public Library of Science, 2012, 8 (7), ⟨10.1371/journal.pgen.1002814⟩
Plos Genetics 7 (8), . (2012)
PLoS Genetics, Vol 8, Iss 7, p e1002814 (2012)
ISSN: 1553-7390
1553-7404
DOI: 10.1371/journal.pgen.1002814⟩
Popis: As sessile organisms, plants have to cope with diverse environmental constraints that may vary through time and space, eventually leading to changes in the phenotype of populations through fixation of adaptive genetic variation. To fully comprehend the mechanisms of evolution and make sense of the extensive genotypic diversity currently revealed by new sequencing technologies, we are challenged with identifying the molecular basis of such adaptive variation. Here, we have identified a new variant of a molybdenum (Mo) transporter, MOT1, which is causal for fitness changes under artificial conditions of both Mo-deficiency and Mo-toxicity and in which allelic variation among West-Asian populations is strictly correlated with the concentration of available Mo in native soils. In addition, this association is accompanied at different scales with patterns of polymorphisms that are not consistent with neutral evolution and show signs of diversifying selection. Resolving such a case of allelic heterogeneity helps explain species-wide phenotypic variation for Mo homeostasis and potentially reveals trade-off effects, a finding still rarely linked to fitness.
Author Summary Plants are studied for their ability to adapt to their environment and especially to the physical constraints to which they are subjected. It is expected that they evolve in promoting genetic variants favorable under their native conditions, which could lead to negative consequences in other conditions. One approach to study the mechanisms and dynamics of these adaptations is to discover genetic variants that control potentially adaptive traits, and to study directly these variants in wild populations to try to reveal their evolutionary trajectory. We have identified a new polymorphism in a gene coding for a transporter of molybdenum (an essential micronutrient for the plant) in Arabidopsis; we show that this variant has strong phenotypic consequences at the level of plant growth and reproductive value in specific conditions, and that it explains a lot of the species diversity for these traits. Especially, the variant is associated with a clear negative effect under molybdenum-deficient conditions (caused by soil acidity) and with a subtle positive effect under molybdenum-plethoric conditions. Interestingly, the landscape distribution of the variant is not random among Asian populations and correlates well with the availability of molybdenum in the soil at the precise location where the plants are growing in the wild.
Databáze: OpenAIRE
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