Unveiling the mystery of mitochondrial DNA replication in yeasts
| Autor: | George Desmond Clark-Walker, Xin Jie Chen |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
DNA Replication
Recombination Genetic 0301 basic medicine Genetics Semiconservative replication DNA replication Eukaryotic DNA replication Saccharomyces cerevisiae Cell Biology Biology DNA Mitochondrial Models Biological Article Cell biology 03 medical and health sciences 030104 developmental biology Replication factor C Control of chromosome duplication Rolling circle replication Molecular Medicine Origin recognition complex Molecular Biology Mitochondrial DNA replication |
| Zdroj: | Mitochondrion. 38:17-22 |
| ISSN: | 1567-7249 |
| DOI: | 10.1016/j.mito.2017.07.009 |
| Popis: | Conventional DNA replication is initiated from specific origins and requires the synthesis of RNA primers for both the leading and lagging strands. In contrast, the replication of yeast mitochondrial DNA is origin-independent. The replication of the leading strand is likely primed by recombinational structures and proceeded by a rolling circle mechanism. The coexistent linear and circular DNA conformers facilitates the recombination-based initiation. The replication of the lagging strand is poorly understood. Re-evaluation of published data suggests that the rolling circle may also provide structures for the synthesis of the lagging-strand by mechanisms such as template switching. Thus, the coupling of recombination with rolling circle replication and possibly, template switching, may have been selected as an economic replication mode to accommodate the reductive evolution of mitochondria. Such a replication mode spares the need for conventional replicative components, including those required for origin recognition/remodelling, RNA primer synthesis and lagging-strand processing. |
| Databáze: | OpenAIRE |
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