Evaluation of retroperitoneal and pelvic lymph node metastases with MRI and MR lymphangiography
| Autor: | M.-F. Bellin, L. Lebleu, J.-B. Meric |
|---|---|
| Rok vydání: | 2003 |
| Předmět: |
Male
medicine.medical_specialty Iron Urology Contrast Media Sensitivity and Specificity Magnetic resonance angiography Metastasis medicine Humans Radiology Nuclear Medicine and imaging Retroperitoneal Neoplasms Magnetite Nanoparticles Lymph node Pelvic Neoplasms Radiological and Ultrasound Technology medicine.diagnostic_test business.industry Gastroenterology Cancer Dextrans Oxides Magnetic resonance imaging General Medicine Mononuclear phagocyte system medicine.disease Magnetic Resonance Imaging Ferrosoferric Oxide medicine.anatomical_structure Lymphatic system Lymphatic Metastasis Female Lymph Nodes Lymph Radiology Tomography X-Ray Computed business Magnetic Resonance Angiography |
| Zdroj: | Abdominal Imaging. 28:155-163 |
| ISSN: | 1432-0509 0942-8925 |
| DOI: | 10.1007/s00261-001-0182-9 |
| Popis: | Local, regional lymph node involvement is an essential prognostic factor and an important determinant of treatment choices for patients with retroperitoneal and pelvic cancer. Current cross-sectional imaging modalities, including computed tomography and magnetic resonance (MR) imaging, use the nonspecific criterion of size and are limited in their ability to differentiate benign from malignant lymph nodes. MR lymphography is a promising imaging modality in differentiating benign from metastatic lymph nodes and provides information on lymph node morphology and function. Ultrasmall superparamagnetic iron oxide (USPIO) particles with a long plasma circulation time are suitable as an MR contrast agent for intravenous MR lymphography. They are taken up by macrophages in normally functioning nodes and reduce the signal intensity of tissue in which they accumulate because of T2 and susceptibility effects of iron oxide. In metastatic nodes, macrophages are replaced by cancer cells, which lack reticuloendothelial activity and cannot take up USPIO. The main mechanisms that might explain a heterogeneous node appearance after USPIO injection are discussed. In published reports, USPIO has shown high degrees of sensitivity and specificity for characterizing lymph nodes in cancer patients. We review the development of USPIO compounds, their imaging characteristics, and our clinical experience. |
| Databáze: | OpenAIRE |
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