Fat-soluble Vitamin Deficiencies and Inflammatory Bowel Disease
| Autor: | Jakub Fichna, Cezary Watala, Natalia Fabisiak, Adam Fabisiak |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
Vitamin
medicine.medical_specialty Vitamin K medicine.medical_treatment Gastroenterology Inflammatory bowel disease 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Crohn Disease Internal medicine medicine Vitamin D and neurology Humans Vitamin E Vitamin D Vitamin A business.industry Albumin Avitaminosis medicine.disease Ulcerative colitis Confidence interval Fat-Soluble Vitamin chemistry 030220 oncology & carcinogenesis Colitis Ulcerative 030211 gastroenterology & hepatology business |
| Zdroj: | Journal of Clinical Gastroenterology. 51:878-889 |
| ISSN: | 0192-0790 |
| DOI: | 10.1097/mcg.0000000000000911 |
| Popis: | Background Vitamin deficiency is frequently associated with inflammatory bowel disease (IBD). Supplementation of vitamins could thus serve as an adjunctive therapy. The present meta-analysis reviews the deficiencies and alterations in serum fat-soluble vitamins (A, D, E, and K) reported in IBD patients. Materials and methods PubMed database search was performed to identify all primary studies up to January 2015 that evaluated the serum concentrations of fat-soluble vitamin levels in IBD patients compared with healthy individuals. We estimated pooled mean differences between groups and estimated their relations with some compounding variables (age, disease duration, C-reactive protein, albumin), using a meta-regression analysis. Results Nineteen case-control studies met selection criteria. In patients with Crohn's disease (CD), vitamin A, D, E, K status was lower than in controls [D=212 μg/L.92; 95% confidence interval (CI), 95.36-330.48 μg/L, P=0.0002; D=6.97 nmol/L, 95% CI, 1.61-12.32 nmol/L, P=0.01; D=4.72 μmol/L, 95% CI, 1.60-7.84 μmol/L, P=0.003; D=1.46 ng/mL, 95% CI, 0.48-2.43 ng/mL, P=0.003, respectively]. Patients with ulcerative colitis had lower levels of vitamin A than controls (D=223.22 μg/L, 95% CI, 44.32-402.12 μg/L, P=0.01). Patients suffering from CD for a longer time had lower levels of vitamins A (95% CI=7.1-67.58 y, P=0.02) and K (95% CI, 0.09-0.71 y, P=0.02). Meta-regression analysis demonstrated statistically significant associations between the levels of inflammatory biomarkers: C-reactive protein (P=0.03, 95% CI, -9.74 to -0.6 mgl/L) and albumin (P=0.0003, 95% CI, 402.76-1361.98 g/dL), and vitamin A status in CD patients. Conclusion Our meta-analysis shows that the levels of fat-soluble vitamins are generally lower in patients with inflammatory bowel diseases and their supplementation is undoubtedly indicated. |
| Databáze: | OpenAIRE |
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