Controlling systolic blood pressure is difficult in patients with diabetic kidney disease exhibiting moderate-to-severe reductions in renal function
| Autor: | Helge Skjønsberg, Dag Paulsen, Dagfinn Dyrbekk, Odd Helge Hunderi, Line Katrine prøsch, Erik Arnesen, Helga Gudmundsdottir, Ingrid Os, Marie Grøn Saelen |
|---|---|
| Rok vydání: | 2005 |
| Předmět: |
medicine.medical_specialty
medicine.medical_treatment Urology Diastole Renal function Angiotensin-Converting Enzyme Inhibitors Blood Pressure Disease Kidney Risk Factors Internal medicine Internal Medicine medicine Humans Diabetic Nephropathies Renal replacement therapy Antihypertensive Agents Aged Diabetic kidney business.industry Norway Blood Pressure Determination General Medicine Middle Aged medicine.disease Health Surveys Blood pressure Endocrinology Cross-Sectional Studies Treatment Outcome Chronic renal failure Kidney Failure Chronic Cardiology and Cardiovascular Medicine business Angiotensin II Type 1 Receptor Blockers Kidney disease |
| Zdroj: | Blood pressure. 14(3) |
| ISSN: | 0803-7051 |
| Popis: | This study compared the use of antihypertensive treatment and blood pressure (BP) controls between patients with diabetic kidney disease (DK+) and patients with non-diabetic kidney disease (DK-) exhibiting moderate-to-severe chronic renal failure who did not need renal replacement therapy. A cross-sectional survey included all renal patients with s-creatinine at ?200 micromol/l attending regular control sessions at six renal units in Norway. Of the 351 patients included, 73 (20.8%) were DK+. The proportion reaching a BP goal of130/80 mmHg was similar in DK+ and DK- (14.1% vs 13.6%, p = 0.92), while 38% and 39% achieved a BP of140/90 mmHg, respectively. The systolic BP goal was more difficult to achieve than the diastolic BP goal in DK+ patients (35% vs 15%) despite a mean of three different types of drugs being used. Loop diuretics and beta-adrenergic-receptor antagonists were the most frequently prescribed drugs, and the use of angiotensin-converting enzyme inhibitors or angiotensin-II-receptor antagonists declined when renal function deteriorated, from 80% to 0% and from 66% to 20% in the DK+ and DK- groups, respectively (p = 0.001). Thus, despite the use of multiple antihypertensive drugs, controlling BP - especially the systolic BP - is difficult in high-risk patients with chronic renal failure caused by diabetic kidney disease. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|