Effects of pregnancy on the solubility of halogenated volatile anaesthetics in rat blood and tissues
| Autor: | Yan Rao, Ye Wang, Weihao Zhang, Haifeng Li, Jianfang Liu |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
Methyl Ethers
medicine.medical_specialty Chromatography Gas Critical Care and Intensive Care Medicine Kidney Blood–gas partition coefficient Sevoflurane Rats Sprague-Dawley Pregnancy Internal medicine medicine Animals Solubility Analysis of Variance Isoflurane business.industry Myocardium Brain medicine.disease Rats Anesthesiology and Pain Medicine Endocrinology medicine.anatomical_structure Liver Anesthesia Anesthetics Inhalation Gestation Female Halothane business medicine.drug |
| Zdroj: | Anaesthesia and intensive care. 36(6) |
| ISSN: | 0310-057X |
| Popis: | This study was designed to evaluate the effects of pregnancy on the solubility of halogenated volatile anaesthetics in rat blood and tissues. Tissue samples from 10 pregnant and 10 non-pregnant adult female Sprague Dawley rats, including the heart, liver, kidney and brain, were obtained and made into respective homogenates. Blood/gas and tissue/gas partition coefficients for halothane, sevoflurane and isoflurane were determined by the method of two-stage headspace equilibration by gas chromatography with each of the homogenates. Values were analysed by t-test or one-way analysis of variance. The solubility within blood and brain for halothane in the pregnant group (2.90 ± 0.44, 5.55 ± 0.73) was significantly lower than that of the non-pregnant group (3.42±0.23, 6.33±0.64; P |
| Databáze: | OpenAIRE |
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