Trimethoprim-sulfamethoxazole vs sulfamethoxazole for acute urinary tract infections in children
| Autor: | Jorge E. Howard, Jorge B. Howard |
|---|---|
| Rok vydání: | 1978 |
| Předmět: |
Male
medicine.medical_specialty Sulfamethoxazole medicine.drug_class Urinary system Antibiotics Gastroenterology Trimethoprim law.invention Blood serum Randomized controlled trial Double-Blind Method law Internal medicine medicine Escherichia coli Humans Child Escherichia coli Infections Clinical Trials as Topic Hematology business.industry Infant Bacteriological Cure Bacterial Infections Surgery Drug Combinations Child Preschool Pediatrics Perinatology and Child Health Acute Disease Urinary Tract Infections Female business medicine.drug |
| Zdroj: | American journal of diseases of children (1960). 132(11) |
| ISSN: | 0002-922X |
| Popis: | • A total of 118 children between 6 months and 10 years of age with acute urinary tract infection were treated in a random; double-blind manner with 12 mg/kg/day of trimethoprim-sulfamethoxazole (61 patients) or 50 mg/kg/day of sulfamethoxazole (57 patients) for ten days. Mean trimethoprim and sulfamethoxazole susceptibilities of Escherichia coli isolated from these patients were 1.2 and 0.6 μg/ml, respectively. Mean serum concentrations of trimethoprim and sulfamethoxazole were 1.8 and 62 μg/ml, respectively, one hour after the dose. Of the children who completed the ten days of prescribed medication, clinical and bacteriological cure was confirmed immediately after treatment for all but one patient in each group. Most patients in each treatment group with recurrent infections had underlying urological abnormalities. Severe hematological, renal, or hepatic toxicity requiring interruption of treatment was not encountered. No advantage of trimethoprim-sulfamethoxazole over sulfamethoxazole alone for acute urinary tract infection was demonstrated. ( Am J Dis Child 132:1085-1087, 1978) |
| Databáze: | OpenAIRE |
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