Inhibitory effect of tyrphostin 47 on Shiga toxin-induced cell death
| Autor: | Hiroko Sonoda, Katsuaki Ito, Shinji Yamasaki, Atsuko Horie, Mariko Shimono, Sayaka Oshikawa, Masahiro Ikeda, Yasuhiro Gunji |
|---|---|
| Rok vydání: | 2006 |
| Předmět: |
MAP Kinase Signaling System
Tyrphostins medicine.disease_cause p38 Mitogen-Activated Protein Kinases Shiga Toxin Chlorocebus aethiops medicine Animals Phosphorylation Protein kinase A Protein Kinase Inhibitors Vero Cells Pharmacology Cell Death biology Toxin Shiga toxin Molecular biology Mitogen-activated protein kinase biology.protein Vero cell sense organs Tyrosine kinase hormones hormone substitutes and hormone antagonists |
| Zdroj: | European Journal of Pharmacology. 546:36-39 |
| ISSN: | 0014-2999 |
| Popis: | The inhibitory effects of tyrosine kinase inhibitors including tyrphostins 25, 47 and 51 on Shiga toxin 1-induced cell death and p38 mitogen-activated protein kinase (p38 MAPK) phosphorylation were examined in Vero cells. Tyrphostin 47 significantly inhibited Shiga toxin 1-induced cell death and p38 MAPK phosphorylation. In contrast, tyrphostins 25 and 51 had no significant effect on the Shiga toxin 1-induced responses. These data indicate that Shiga toxin 1-induced cell injury occurs through a pathway sensitive to tyrphostin 47, and the target molecule for tyrphostin 47 opens up new opportunities for pharmacological intervention against Shiga toxin-producing Escherichia coli infectious diseases. |
| Databáze: | OpenAIRE |
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