Serum cartilage oligomeric matrix protein is decreased in patients with pulmonary hypertension: a potential protective factor
| Autor: | Dong Liu, Shanqun Li, Liang Xie, Li-Hua Guan, Qinhan Wu, Weiping Hu, Dan-Dan Chen, Guiling Xiang, Jie-Ming Qu |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Pulmonary and Respiratory Medicine
musculoskeletal diseases medicine.medical_specialty Population Protective factor Hemodynamics Diseases of the respiratory system Internal medicine medicine Diseases of the circulatory (Cardiovascular) system In patient pulmonary hypertension (PH) Original Research Article education Cartilage oligomeric matrix protein education.field_of_study biology RC705-779 business.industry tricuspid annular plane systolic excursion (TAPSE) cartilage oligomeric matrix protein (COMP) Hypoxia (medical) medicine.disease musculoskeletal system Pulmonary hypertension carbohydrates (lipids) RC666-701 biology.protein Cardiology Etiology medicine.symptom business |
| Zdroj: | Pulmonary Circulation, Vol 11 (2021) Pulmonary Circulation |
| ISSN: | 2045-8940 |
| Popis: | Cartilage oligomeric matrix protein (COMP) was a protective factor in the cardiovascular system. Previous studies showed that hypoxia led to decreased COMP in rat models of pulmonary hypertension. However, the expression pattern of COMP in the pulmonary hypertension population was unclear. A total of 35 patients newly diagnosed with pulmonary hypertension and 70 controls were enrolled in the study. Circulating COMP concentrations of serum samples were measured by enzyme-linked immunosorbent assay and were analyzed the association with multiple clinical variables. Serum COMP concentrations in the pulmonary hypertension group were significantly declined in comparison with age- and sex-matched normal controls, especially in the female subgroup. No significant difference of COMP concentrations was observed in the etiological classification, heart function classification, and risk stratification. Major hemodynamic parameters, six-minute walk distance, N-terminal pro brain natriuretic peptide, and short-term prognosis were not statistically associated with COMP. However, some echocardiography parameters, like tricuspid annular plane systolic excursion and mean right atrial pressure, were found the negative relation to COMP concentrations. In conclusion, serum COMP levels were decreased in the patients with pulmonary hypertension, which was in accordance with its known biological effects. Its association with long-term prognosis was worth further exploring. |
| Databáze: | OpenAIRE |
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