Potential remote drug delivery failures due to temperature-dependent viscosity and drug-loss of aqueous and emulsion-based fluids
| Autor: | Cristiane Schilbach Pizzutto, Alfred Acosta, Derek Andrew Rosenfield, Denise Trigilio Tavares |
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| Rok vydání: | 2021 |
| Předmět: |
Drug
030213 general clinical medicine Aqueous solution INJEÇÃO 040301 veterinary sciences Chemistry media_common.quotation_subject Temperature dependent viscosity 04 agricultural and veterinary sciences Management Monitoring Policy and Law 0403 veterinary science 03 medical and health sciences 0302 clinical medicine Chemical engineering Drug delivery Emulsion Animal Science and Zoology Ecology Evolution Behavior and Systematics Nature and Landscape Conservation media_common |
| Zdroj: | Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual) Universidade de São Paulo (USP) instacron:USP |
| Popis: | The ability to inject wild animals from a distance using remote drug delivery systems (RDDS) is one of the most effective and humane practices in wildlife management. Several factors affect the successful administration of drugs using RDDS. For example, temperature-dependent viscosity change in aqueous (Newtonian) or water-in-oil emulsion (non-Newtonian) fluids, commonly used in tranquilizer and adjuvant-based vaccines, respectively, can potentially result in drug delivery failure. To better understand impacts due to viscosity changes, we investigated the fluid dynamics and ballistics involved in remote drug delivery. Our research was divided into two phases: we investigated the viscosimetric physics in the first phase to determine the fluid behavior under different temperature settings, simulating recommended storage temperature (7ºC), plus an ambient temperature (20ºC). In the second phase of our study, we assessed the drug delivery efficiency by specialized darts, using a precision CO2 projector and a blowgun. Efficiency assessment was done by comparing the original drug volume with the actual volume injected after firing the dart into a fresh pork hide mounted on a ballistic gel. Before testing, we configured the required minimum impact velocity for our parameters and intramuscular injection (determined as ˃ 40 m/sec). All executed dart-deployments performed satisfactorily, despite initial concerns of potential incomplete drug delivery, however, noteworthy drug loss was observed (˃10%) associated with drug residues in syringe/dart dead space and within the transfer needle. This could potentially result in inaccurate dosing depending on the drug used. Furthermore, the use of a blowgun for remote drug delivery (>3m) is discouraged, especially when using specialized darts, as the required minimum dart velocity for adequate penetration is difficult to reach, in addition to a loss of precision during targeting. |
| Databáze: | OpenAIRE |
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