Neuroprotection of Cilostazol against ischemia/reperfusion-induced cognitive deficits through inhibiting JNK3/caspase-3 by enhancing Akt1
| Autor: | Jin-hao Tao, Da-Shi Qi, Pei Liu, Fayong Zhang, Fuming Liu, Xin-Yu Mei, Jing-Yi Ma, Mei Wang, Jian-Cheng Miu, Rui Qu, Lian-Qin Zhang, Shi-Chun Zhang, Man Li |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Male
0301 basic medicine Drug Evaluation Preclinical Tetrazoles Morris water navigation task Apoptosis Pharmacology Hippocampus Neuroprotection Open field Brain Ischemia Rats Sprague-Dawley Brain ischemia 03 medical and health sciences 0302 clinical medicine Mitogen-Activated Protein Kinase 10 medicine Animals Enzyme Inhibitors Phosphorylation Molecular Biology Cognitive deficit Neurons Caspase 3 General Neuroscience medicine.disease Cilostazol Disease Models Animal CTL Neuroprotective Agents 030104 developmental biology Reperfusion Injury Neurology (clinical) medicine.symptom Alzheimer's disease Cognition Disorders Psychology Proto-Oncogene Proteins c-akt Neuroscience 030217 neurology & neurosurgery Developmental Biology medicine.drug |
| Zdroj: | Brain Research. 1653:67-74 |
| ISSN: | 0006-8993 |
| DOI: | 10.1016/j.brainres.2016.10.017 |
| Popis: | Cilostazol(CTL) is a phosphodiesterase inhibitor, which has been widely used as anti-platelet agent. It also has preventive effects on various central nervous system (CNS) diseases, including ischemic stroke, Parkinson's disease and Alzheimer disease. However, the molecular mechanism underlying the protective effects of CTL is still unclear, and whether CTL can prevent I/R induced cognitive deficit has not been reported. Transient global brain ischemia was induced by 4-vessel occlusion in adult male Sprague-Dawley rats. The open field tasks and Morris water maze were used to assess the effect of CTL on anxiety-like behavioral and cognitive impairment after I/R. Western blotting were performed to examine the expression of related proteins, and HE-staining was used to detect the percentage of neuronal death in the hippocampal CA1 region. Here we found that CTL significantly improved cognitive deficits and the behavior of rats in Morris water maze and open field tasks (P |
| Databáze: | OpenAIRE |
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