Assessing drivers of the IgG4 antibody reactivity to recombinant antigen Bm14 in Wuchereria bancrofti endemic populations in East Africa
| Autor: | Stephen M. Magesa, Dunstan A. Mukoko, Paul E. Simonsen, Johanne Damgaard, Dan W. Meyrowitsch, R.T. Rwegoshora |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
Adult
Male Adolescent Veterinary (miscellaneous) 030231 tropical medicine Population Antibodies Helminth medicine.disease_cause Filariasis 03 medical and health sciences 0302 clinical medicine Elephantiasis Filarial Sex Factors Antigen parasitic diseases medicine Helminths Animals Humans Wuchereria bancrofti 030212 general & internal medicine Vector (molecular biology) education Child Microfilariae Lymphatic filariasis Aged Aged 80 and over education.field_of_study biology fungi Age Factors Africa Eastern Middle Aged medicine.disease Virology Infectious Diseases Insect Science Antigens Helminth Child Preschool Immunoglobulin G Immunology biology.protein Parasitology Female Antibody Biomarkers |
| Zdroj: | Acta tropica. 161 |
| ISSN: | 1873-6254 |
| Popis: | A high proportion of the human population in lymphatic filariasis (LF) endemic areas is positive for filarial specific IgG4 antibodies, including many individuals without microfilariae (mf; circulating larvae in the human blood) or circulating filarial antigens (CFA; marker of adult worm infection). The antibodies are commonly regarded as markers of infection and/or exposure to filarial larvae, but a direct association between the antibodies and these indices has not been well documented. The present study assessed the role and relative effect of potential drivers of the human IgG4 antibody reactivity to the recombinant filarial antigen Bm14 in Wuchereria bancrofti endemic populations in East Africa. Sera collected during previous studies from 395 well characterized individuals with regard to age, sex, mf, CFA, household vector biting and household exposure to infective filarial larvae were tested for IgG4 antibodies to Bm14, and associations between antibody reactivity and the different variables were statistically analyzed. IgG4 reactivity to Bm14 was highly positively associated with CFA, and to a lesser extent with age. However, an expected association with household exposure to infective filarial larvae was not found. Bm14 antibody reactivity thus appeared mainly to reflect actual infection of individuals with adult filarial worms rather than ongoing exposure to transmission. The analyses moreover suggested that many of the CFA negative but Bm14 positive individuals had early or low level infections where antibodies had been induced but where CFA was not (yet?) measurable. Although the study indicated that IgG4 reactivity to Bm14 is a marker of filarial infection, assessment of this reactivity, especially in children, will still be useful for indirect monitoring of changes in transmission intensity, including break of transmission and post-elimination surveillance, in LF control. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect