8th European Conference on Infections in Leukaemia: 2020 guidelines for the use of antibiotics in paediatric patients with cancer or post-haematopoietic cell transplantation
| Autor: | Jukka Kanerva, Fanny Lanternier, Monica A. Slavin, Elio Castagnola, Andreas H. Groll, Dina Averbuch, Alessio Mesini, Roland A. Ammann, Carolina Garcia-Vidal, Simone Cesaro, Malgorzata Mikulska, Nicole Ritz, Jan Styczyński, Dorothea Pana, Adilia Warris, Thomas Lehrnbecher |
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| Přispěvatelé: | HUS Children and Adolescents, Children's Hospital |
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
medicine.drug_class medicine.medical_treatment 3122 Cancers Antibiotics Placebo-controlled study CHILDREN Guidelines as Topic Hematopoietic stem cell transplantation PLACEBO-CONTROLLED TRIAL INTRAVENOUS ANTIBIOTICS Pediatrics ANTIBACTERIAL PROPHYLAXIS CIPROFLOXACIN PROPHYLAXIS 03 medical and health sciences 0302 clinical medicine Internal medicine medicine Humans 030212 general & internal medicine LACTAMASE-PRODUCING ENTEROBACTERIACEAE RISK FEBRILE NEUTROPENIA 610 Medicine & health Adverse effect Leukemia business.industry Hematopoietic Stem Cell Transplantation Cancer Congresses as Topic medicine.disease Anti-Bacterial Agents 3. Good health Discontinuation ONCOLOGY PATIENTS Mycoses Oncology 030220 oncology & carcinogenesis OUTPATIENT MANAGEMENT BLOOD-STREAM INFECTIONS business Febrile neutropenia |
| Zdroj: | The Lancet Oncology. 22:e270-e280 |
| ISSN: | 1470-2045 |
| DOI: | 10.1016/s1470-2045(20)30725-7 |
| Popis: | Paediatric patients with cancer and those undergoing haematopoietic cell transplantation are at high risk of bacterial infections. The 8th European Conference on Infections in Leukaemia (ECIL-8) convened a Paediatric Group to review the literature and to formulate recommendations for the use of antibiotics according to the European Society of Clinical Microbiology and Infectious Diseases grading system. The evaluation of antibacterial prophylaxis included mortality, bloodstream infection, febrile neutropenia, emergence of resistance, and adverse effects as endpoints. Initial antibacterial therapy and antibiotic de-escalation or discontinuation focused on patients with a clinically stable condition and without previous infection or colonisation by resistant bacteria, and on patients with a clinically unstable condition or with previous infection or colonisation by resistant bacteria. The final considerations and recommendations of the ECIL-8 Paediatric Group on antibacterial prophylaxis, initial therapy, and de-escalation strategies are summarised in this Policy Review. |
| Databáze: | OpenAIRE |
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