The interval between onset and admission predicts disease progression in COVID-19 patients
| Autor: | Wen-Hao Huang, Yi Wei, Liang Peng, Renqiang Ma, Kejing Tang, Fan Yang, Yong-Quan Wang, Chun-Wei Li, Weiping Wen, Qing-Quan Lv, Xing-mei Wu, Cheng-Cheng Zhang, Lin Yao, Jian Li |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
business.industry Medical record Retrospective cohort study General Medicine Odds ratio 030204 cardiovascular system & hematology Logistic regression Confidence interval 03 medical and health sciences 0302 clinical medicine Internal medicine medicine Mann–Whitney U test Medical history Original Article 030212 general & internal medicine Stage (cooking) business |
| Zdroj: | Ann Transl Med |
| Popis: | Background The prognostic role of the interval between disease onset and hospital admission (O-A interval) was undetermined in patients with the coronavirus disease 2019 (COVID-19). Methods A total of 205 laboratory-confirmed inpatients admitted to Hankou hospital of Wuhan from January 11 to March 8, 2020 were consecutively included in this retrospective observational study. Demographic data, medical history, laboratory testing results were collected from medical records. Univariate and multivariate logistic regression models were used to evaluate the prognostic effect of the O-A interval (≤7 versus >7 days) on disease progression in mild-to-moderate patients. For severe-to-critical patients, the in-hospital mortality and the length of hospital stay were compared between the O-A interval subgroups using log-rank test and Mann-Whitney U test, respectively. Results Mild-to-moderate patients with a short O-A interval (≤7 days) are more likely to deteriorate to severe-to-critical stage compared to those with a long O-A interval (>7 days) [unadjusted odds ratio =2.93, 95% confidence interval (CI), 1.32-6.55; adjusted odds ratio =3.44, 95% CI, 1.20-9.83]. No association was identified between the O-A interval and the mortality or the length of hospital stay of severe-to-critical patients. Conclusions The O-A interval has predictive values for the disease progression in mild-to-moderate COVID-19 patients. Under circumstances of the specific health system in Wuhan, China, the spontaneous healthcare-seeking behavior is usually determined by patients' own heath conditions. Hence, the O-A interval can be reflective of the natural course of COVID-19 to some extent. However, our findings should be validated further in other cohorts and in other health systems. |
| Databáze: | OpenAIRE |
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