COVID-19 outbreak in Jordan: Epidemiological features, clinical characteristics, and laboratory findings
| Autor: | Samah Awad, Ali M. Ibnian, Musa K. Al-Ali, Shaher M Samrah, Suleiman M. Momany, Wail A. Hayajneh, Dawood Yusef, Abdel-Hameed Al-Mistarehi, Liqaa Raffee, Basheer Khassawneh |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
Nasal congestion Erythrocyte sedimentation rate Asymptomatic Article c-Reactive protein 03 medical and health sciences 0302 clinical medicine Internal medicine Epidemiology Sore throat Medicine BCG Jordan medicine.diagnostic_test biology business.industry SARS-CoV-2 C-reactive protein Outbreak COVID-19 Retrospective cohort study General Medicine Coronavirus 030220 oncology & carcinogenesis D-dimer biology.protein 030211 gastroenterology & hepatology Surgery medicine.symptom business |
| Zdroj: | Annals of Medicine and Surgery |
| ISSN: | 2049-0801 |
| DOI: | 10.1016/j.amsu.2020.07.020 |
| Popis: | Background In March 2020, an outbreak of coronavirus 19 (COVID-19) was detected in the North of Jordan. This retrospective study is the first from Jordan to report the epidemiologic, clinical, laboratory, and radiologic characteristics of COVID-19 infected patients. Methods All patients with laboratory-confirmed COVID-19 infection by RT-PCR in the North of Jordan admitted between March 15 and April 2, 2020 were included. The clinical features, radiological, and laboratory findings were reviewed. Results Of 81 patients affected, 79 (97.5%) shared a common exposure to four recent travelers from endemic areas. The mean age was 40 years. Although about half (44 [54.3%]) were females, symptomatic patients were mostly females (75%). The most common presenting symptoms were nasal congestion, sore throat and dry cough. Less than one-third (31%) had chronic diseases. Although 84% of patients reported receiving Bacille Calmette-Guérin (BCG) vaccination, more asymptomatic patients had BCG than symptomatic (p = 0.017). Almost all patients (97.5%) had an elevated D-dimer level. Erythrocyte sedimentation rate (ESR) and c-reactive protein were elevated in 50% and 42.7% of patients, respectively. High ESR found to be the predictor of abnormal chest radiograph observed in 13 (16%) patients with OR of 14.26 (95% CI 1.37–147.97, p = 0.026). Conclusions An outbreak of COVID-19 infection in northern Jordan affected more females and relatively young individuals and caused mainly mild illnesses. The strict outbreak response measures applied at early stages probably contributed to the lenient nature of this outbreak, but the contribution of other factors to such variability in COVID-19 presentation is yet to be explained. Highlights • A COVID-19 outbreak in northern Jordan caused mild illness presentation and most cases shared a common exposure. • Young individuals and females were mainly affected in this outbreak. • The majority and more of the asymptomatic patients, reported receiving BCG immunization. • Inflammatory markers were elevated in most cases and Elevated ESR was a predictor to abnormal chest radiograph findings. • Early and strict response measures limited COVID-19 spread in Jordan and contributed to the lenient nature of the outbreak. |
| Databáze: | OpenAIRE |
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