Ulapualides C-E Isolated from a Hawaiian Hexabranchus sanguineus Egg Mass
| Autor: | Philip G. Williams, Stephen M. Parrish, Baojun Yang, Wesley Y. Yoshida |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
Egg masses
Stereochemistry Gastropoda Pharmaceutical Science Marine Biology 010402 general chemistry 01 natural sciences Hawaii Article Analytical Chemistry Ulapualide C Drug Discovery Hexabranchus Animals Humans Cytotoxicity Oxazoles Ovum Pharmacology biology Molecular Structure 010405 organic chemistry Organic Chemistry Nudibranch Anatomy biology.organism_classification 0104 chemical sciences Complementary and alternative medicine Molecular Medicine Drug Screening Assays Antitumor |
| Zdroj: | Journal of natural products. 80(3) |
| ISSN: | 1520-6025 |
| Popis: | Three new ulapualides (3-5) were isolated from egg masses of the nudibranch Hexabranchus sanguineus. The structures of 3-5 were deduced by analyses of physical and spectroscopic data in comparisons with ulapualides A (1) and B (2). Ulapualide C demonstrated submicromolar cytotoxicity against select NCI cell lines (768-0, DU-145, MDA-MB-231, and A549) with the most potent activity against MDA-MB-231 cells (IC50 0.58 μM). Ulapualides A (1) and B (2) were 2- to 4-fold more potent than 3. |
| Databáze: | OpenAIRE |
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