VCAM-1 upregulation accompanies muscle remodeling following resistance-type exercise in Snell dwarf (Pit1dw/dw ) mice

Autor: Marshall A. Naimo, Erik P. Rader, James Ensey, Brent A. Baker
Rok vydání: 2018
Předmět:
Vascular Endothelial Growth Factor A
Aging
medicine.medical_specialty
Muscle Fibers
Skeletal
Vascular Cell Adhesion Molecule-1
030209 endocrinology & metabolism
Context (language use)
Hypopituitarism
Biology
Mice
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Thyroid-stimulating hormone
Downregulation and upregulation
Physical Conditioning
Animal
Internal medicine
medicine
Animals
skeletal muscle
VCAM-1
Progenitor cell
Dwarfism
Pituitary
Muscle
Skeletal
Original Paper
dorsiflexor muscles
agonist muscles
Body Weight
Skeletal muscle
antagonist muscles
Organ Size
030229 sport sciences
Cell Biology
medicine.disease
Original Papers
Prolactin
Up-Regulation
plantarflexor muscles
medicine.anatomical_structure
Endocrinology
chemistry
Muscle Fatigue
stretch‐shortening contractions
Zdroj: Aging Cell
ISSN: 1474-9718
DOI: 10.1111/acel.12816
Popis: Snell dwarf mice (Pit1dw/dw) exhibit deficiencies in growth hormone, prolactin, and thyroid stimulating hormone. Besides being an experimental model of hypopituitarism, these mice are long‐lived (>40% lifespan extension) and utilized as a model of slowed/delayed aging. Whether this longevity is accompanied by a compromised quality of life in terms of muscular performance has not yet been characterized. In this study, we investigated nontrained and trained muscles 1 month following a general validated resistance‐type exercise protocol in 3‐month‐old Snell dwarf mice and control littermates. Nontrained Snell dwarf gastrocnemius muscles exhibited a 1.3‐fold greater muscle mass to body weight ratio than control values although muscle quality, maximum isometric torque normalized to muscle mass, and fatigue recovery were compromised. For control mice, training increased isometric torque (17%) without altering muscle mass. For Snell dwarf mice, isometric torque was unaltered by training despite decreased muscle mass that rendered muscle mass to body weight ratio comparable to control values. Muscle quality and fatigue recovery improved twofold and threefold, respectively, for Snell dwarf mice. This accompanied a fourfold increase in levels of vascular cell adhesion molecule‐1 (VCAM‐1), a mediator of progenitor cell recruitment, and muscle remodeling in the form of increased number of central nuclei, additional muscle fibers per unit area, and altered fiber type distribution. These results reveal a trade‐off between muscle quality and longevity in the context of anterior pituitary hormone deficiency and that resistance‐type training can diminish this trade‐off by improving muscle quality concomitant with VCAM‐1 upregulation and muscle remodeling.
Databáze: OpenAIRE
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