Visceral leishmaniasis masquerading as drug-induced pancytopenia in myasthenia gravis
| Autor: | Gaurav Dhingra, Shweta Azad, Uttam Kumar Nath, Debmalya Bhattacharyya, Debranjani Chattopadhya, Aroop Mohanty |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Male
Pancytopenia Leishmania donovani Azathioprine Diagnosis Differential hemic and lymphatic diseases parasitic diseases Myasthenia Gravis medicine Eosinopenia Humans Pharmacology (medical) General Pharmacology Toxicology and Pharmaceutics Travel biology medicine.diagnostic_test business.industry Muscle weakness General Medicine Middle Aged medicine.disease biology.organism_classification Myasthenia gravis Bone marrow examination Visceral leishmaniasis Immunology Leishmaniasis Visceral medicine.symptom business Immunosuppressive Agents medicine.drug |
| Zdroj: | Drug discoveriestherapeutics. 15(1) |
| ISSN: | 1881-784X |
| Popis: | Visceral leishmaniasis (VL), also known as kala-azar (black fever in Hindi), is a disease primarily caused by Leishmania donovani. The most important clinical manifestation of visceral leishmaniasis is fever. Nonspecific laboratory findings of visceral leishmaniasis include anemia, neutropenia, eosinopenia, and thrombocytopenia. Definitive diagnosis of visceral leishmaniasis requires the demonstration of either parasite by smear or tissue by culture (usually bone marrow or spleen). Myasthenia gravis is an autoimmune disease caused by antibodies to acetylcholine receptors in the post-junctional membrane of the neuromuscular junction. It typically presents with fatigable muscle weakness without any sensory or brain involvement. It is usually treated with corticosteroids and immunosuppressants like azathioprine. Here we encountered a confirmed case of myasthenia gravis on azathioprine with pancytopenia. While working up to evaluate pancytopenia, bone marrow examination revealed presence of Donovan bodies and the patient showed good response to liposomal amphotericin-B. In retrospect, a case of myasthenia gravis, who presented with pancytopenia presumably drug-induced, was found to have visceral leishmaniasis. |
| Databáze: | OpenAIRE |
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