The incidence and prevalence of systemic lupus erythematosus in the UK, 1999–2012
| Autor: | Michael Doherty, Frances Rees, Peter Lanyon, Weiya Zhang, Graham Davenport, Matthew J. Grainge |
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| Rok vydání: | 2014 |
| Předmět: |
Male
0301 basic medicine Pediatrics Epidemiology Ethnic group 0302 clinical medicine Autoimmune Diseases Epidemiology systemic lupus erythematosus immune system diseases Prevalence Lupus Erythematosus Systemic Immunology and Allergy Medicine Young adult Child skin and connective tissue diseases Aged 80 and over Systemic lupus erythematosus Incidence Medical record Incidence (epidemiology) Age Factors Middle Aged Connective tissue disease Caribbean Region Child Preschool Female Adult medicine.medical_specialty Adolescent Immunology Black People Systemic Lupus Erythematosus White People General Biochemistry Genetics and Molecular Biology Autoimmune Diseases Young Adult 03 medical and health sciences Sex Factors Rheumatology Humans Aged Retrospective Studies 030203 arthritis & rheumatology business.industry Retrospective cohort study Clinical and Epidemiological Research medicine.disease United Kingdom 030104 developmental biology business |
| Zdroj: | Annals of the Rheumatic Diseases |
| ISSN: | 1468-2060 0003-4967 |
| DOI: | 10.1136/annrheumdis-2014-206334 |
| Popis: | Objectives: To estimate the incidence and prevalence of systemic lupus erythematosus (SLE) in the UK over the period 1999–2012.\ud \ud Methods: A retrospective cohort study using the Clinical Practice Research Datalink (CPRD). The incidence was calculated per 100 000 person-years and the prevalence was calculated per 100 000 people for the period 1999–2012 and stratified by year, age group, gender, region and ethnicity. Three definitions of SLE were explored: (1) systemic lupus, (2) a fully comprehensive definition of lupus including cutaneous only lupus and (3) requiring supporting evidence of SLE in the medical record.\ud \ud Results: Using our primary definition of SLE, the incidence during the study period was 4.91/100 000 person-years (95% CI 4.73 to 5.09), with an annual 1.8% decline (p |
| Databáze: | OpenAIRE |
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