Effects of Physical Exercise on Autophagy and Apoptosis in Aged Brain: Human and Animal Studies
| Autor: | Paloma Segura de Mello, Amanda Midori Matumoto, Elisa Mitiko Kawamoto, Josiane N. Silva, Diana Zukas Andreotti, Ana Maria Marques Orellana |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
autophagy Brain development Endocrinology Diabetes and Metabolism brain Physical activity 030209 endocrinology & metabolism Physical exercise lcsh:TX341-641 Review 03 medical and health sciences 0302 clinical medicine Medicine Organism Nutrition 030109 nutrition & dietetics Nutrition and Dietetics Preventive strategy exercise business.industry Autophagy aging apoptosis Apoptosis LISOSSOMOS Animal studies business Neuroscience lcsh:Nutrition. Foods and food supply Food Science |
| Zdroj: | Frontiers in Nutrition, Vol 7 (2020) Frontiers in Nutrition Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual) Universidade de São Paulo (USP) instacron:USP |
| DOI: | 10.3389/fnut.2020.00094/full |
| Popis: | The aging process is characterized by a series of molecular and cellular changes over the years that could culminate in the deterioration of physiological parameters important to keeping an organism alive and healthy. Physical exercise, defined as planned, structured and repetitive physical activity, has been an important force to alter physiology and brain development during the process of human beings' evolution. Among several aspects of aging, the aim of this review is to discuss the balance between two vital cellular processes such as autophagy and apoptosis, based on the fact that physical exercise as a non-pharmacological strategy seems to rescue the imbalance between autophagy and apoptosis during aging. Therefore, the effects of different types or modalities of physical exercise in humans and animals, and the benefits of each of them on aging, will be discussed as a possible preventive strategy against neuronal death. |
| Databáze: | OpenAIRE |
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