Navigational cue effects in Alzheimer's disease and posterior cortical atrophy

Autor:	Julia Langham, Sebastian J. Crutch, Catherine Holloway, Ross W. Paterson, B Yang, Teresa Poole, Catherine F. Slattery, Alexander J.M. Foulkes, Keir X.X. Yong, Ian McCarthy, Derrick Boampong, Nikolaos N. Papadosifos, Jonathan M. Schott, Tatsuto Suzuki, Nick Tyler, Chris Frost, Amelia M. Carton
Rok vydání:	2018
Předmět:	medicine.medical_specialty business.industry General Neuroscience media_common.quotation_subject 05 social sciences Posterior cortical atrophy Spatial memory 050105 experimental psychology Motion (physics) Task (project management) 03 medical and health sciences 0302 clinical medicine Physical medicine and rehabilitation Perception Fixation (visual) Medicine Contrast (vision) 0501 psychology and cognitive sciences Neurology (clinical) business Sensory cue 030217 neurology & neurosurgery media_common
Zdroj:	Annals of Clinical and Translational Neurology. 5:697-709
ISSN:	2328-9503
Popis:	OBJECTIVE: Deficits in spatial navigation are characteristic and disabling features of typical Alzheimer's disease (tAD) and posterior cortical atrophy (PCA). Visual cues have been proposed to mitigate such deficits; however, there is currently little empirical evidence for their use. METHODS: The effect of visual cues on visually guided navigation was assessed within a simplified real‐world setting in individuals with tAD (n = 10), PCA (n = 8), and healthy controls (n = 12). In a repeated‐measures design comprising 36 trials, participants walked to a visible target destination (an open door within a built environment), with or without the presence of an obstacle. Contrast and motion‐based cues were evaluated; both aimed to facilitate performance by applying perceptual changes to target destinations without carrying explicit information. The primary outcome was completion time; secondary outcomes were measures of fixation position and walking path directness during consecutive task phases, determined using mobile eyetracking and motion capture methods. RESULTS: Results illustrate marked deficits in patients’ navigational ability, with patient groups taking an estimated two to three times longer to reach target destinations than controls and exhibiting tortuous walking paths. There were no significant differences between tAD and PCA task performance. Overall, patients took less time to reach target destinations under cue conditions (contrast‐cue: 11.8%; 95% CI: [2.5, 20.3]) and were more likely initially to fixate on targets. INTERPRETATION: The study evaluated navigation to destinations within a real‐world environment. There is evidence that introducing perceptual changes to the environment may improve patients’ navigational ability.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae5c6f1a7cb5cf8e99c6278ca390c638 https://doi.org/10.1002/acn3.566 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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