Clinical features and risk factors for severe influenza in children: A study from multiple hospitals in Shanghai
| Autor: | Mengmeng Ge, Jin Xu, Aizhen Lu, Chuanqing Wang, Yu Shi, Xiao-Wen Zhai, Guoping Lu, Hairong Gong, Chengjun Sun, Gongbao Liu, Mei Zeng, Libo Wang, Guo-Mei Shen, Weiming Chen |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Oseltamivir
Pediatrics medicine.medical_specialty ARDS China severe risks Encephalopathy influenza-associated encephalitis RJ1-570 03 medical and health sciences chemistry.chemical_compound Epilepsy 0302 clinical medicine children Risk Factors 030225 pediatrics Influenza Human medicine Humans 030212 general & internal medicine Child Retrospective Studies Coma Septic shock business.industry Incidence (epidemiology) medicine.disease Hospitals chemistry Case-Control Studies Pediatrics Perinatology and Child Health medicine.symptom influenza business Encephalitis |
| Zdroj: | Pediatrics and Neonatology, Vol 62, Iss 4, Pp 428-436 (2021) |
| ISSN: | 2212-1692 |
| Popis: | Background The incidence and mortality of influenza in children had risen, but data are limited on children with severe influenza virus infection in China. Methods We conducted a retrospective case–control study and collected the patients' clinical data. Clinical data including demography, clinical presentation, laboratory findings, radiologic findings, treatment and outcomes were collected. Children were clinically confirmed to have virus infection in Shanghai in three hospitals from June 2014 to June 2019. Results During the study, 36,047 children were enrolled. Among them, 118 met the criteria for severe flu. Clinical symptoms such as fever, cough, gastrointestinal symptoms, coma and epilepsy were higher in the severe group. Complications such as pneumorrhagia, heart failure, septic shock, acute renal failure and influenza-associated encephalitis were higher in the severe influenza group than the death group. The laboratory findings including decreased hemoglobin, high alanine aminotransferase, high urea nitrogen and high lactate levels were risk factors for death in children with influenza. Conclusion Influenza-associated encephalopathy (IAE), acute respiratory distress syndrome (ARDS) were the common clinical manifestations and complications for the severe influenza, and delayed use of oseltamivir was found to be associated with fatality. |
| Databáze: | OpenAIRE |
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