Association of glucocorticoid receptor polymorphisms with clinical and metabolic profiles in polycystic ovary syndrome
| Autor: | Gustavo Arantes Rosa Maciel, Sylvia Asaka Yamashita Hayashida, Berenice B. Mendonca, Diogo Diniz Gomes Bugano, Ricardo P. P. Moreira, J. A. M. Marcondes, Larissa G. Gomes, Edmund Chada Baracat, Tânia A.S.S. Bachega |
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| Jazyk: | angličtina |
| Rok vydání: | 2014 |
| Předmět: |
Adult
medicine.medical_specialty Time Factors Fluoroimmunoassay Biology Glucocorticoid Receptor Polymerase Chain Reaction Statistics Nonparametric Body Mass Index Young Adult Sex hormone-binding globulin Insulin resistance Glucocorticoid receptor Receptors Glucocorticoid Gene Frequency Risk Factors Internal medicine Diabetes mellitus medicine Humans Obesity Alleles Metabolic Syndrome lcsh:R5-920 Metabolic Profile Polymorphism Genetic General Medicine Clinical Science medicine.disease Glucocorticoid Receptor Gene Polymorphisms Polycystic ovary Genes bcl-1 Endocrinology NR3C1 Protein Cholesterol Hypertension biology.protein Female Gene polymorphism Metabolic syndrome Insulin Resistance lcsh:Medicine (General) Glucocorticoid medicine.drug Polycystic Ovary Syndrome |
| Zdroj: | Clinics Clinics, Volume: 69, Issue: 3, Pages: 179-184, Published: MAR 2014 Clinics, Vol 69, Iss 3, Pp 179-184 (2014) Clinics; v. 69 n. 3 (2014); 179-184 Clinics; Vol. 69 Núm. 3 (2014); 179-184 Clinics; Vol. 69 No. 3 (2014); 179-184 Universidade de São Paulo (USP) instacron:USP |
| ISSN: | 1980-5322 1807-5932 |
| Popis: | OBJECTIVES: We aimed to investigate whether glucocorticoid receptor gene polymorphisms are associated with clinical and metabolic profiles in patients with polycystic ovary syndrome. Polycystic ovary syndrome is a complex endocrine disease that affects 5-8% of women and may be associated with metabolic syndrome, which is a risk factor for cardiovascular disease. Cortisol action and dysregulation account for metabolic syndrome development in the general population. As glucocorticoid receptor gene (NR3C1) polymorphisms regulate cortisol sensitivity, we hypothesized that variants of this gene may be involved in the adverse metabolic profiles of patients with polycystic ovary syndrome. METHOD: Clinical, metabolic and hormonal profiles were evaluated in 97 patients with polycystic ovary syndrome who were diagnosed according to the Rotterdam criteria. The alleles of the glucocorticoid gene were genotyped. Association analyses were performed using the appropriate statistical tests. RESULTS: Obesity and metabolic syndrome were observed in 42.3% and 26.8% of patients, respectively. Body mass index was positively correlated with blood pressure, triglyceride, LDL-c, total cholesterol, glucose and insulin levels as well as HOMA-IR values and inversely correlated with HDL-c and SHBG levels. The BclI and A3669G variants were found in 24.7% and 13.4% of alleles, respectively. BclI carriers presented a lower frequency of insulin resistance compared with wild-type subjects. CONCLUSION: The BclI variant is associated with a lower frequency of insulin resistance in women with polycystic ovary syndrome. Glucocorticoid gene polymorphism screening during treatment of the syndrome may be useful for identifying subgroups of at-risk patients who would benefit the most from personalized treatment. |
| Databáze: | OpenAIRE |
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