‘Two countries-two labs’: the transnational gamete donation (TGD) programme to support egg donation

Autor: Francesco Bertocci, Elisabetta Micelli, Maria Elisabetta Coccia, Laura Badolato, Rita Picone, Francesca Rizzello, Luciana Criscuoli, Savio Wakunga, Giachini Claudia, Paolo Evangelisti
Rok vydání: 2020
Předmět:
Male
0301 basic medicine
Pregnancy Rate
medicine.medical_treatment
Egg donation
0302 clinical medicine
Human fertilization
Pregnancy
Prospective Studies
Assisted Reproduction Technologies
Genetics (clinical)
030219 obstetrics & reproductive medicine
Oocyte Donation
Assisted reproduction
Obstetrics and Gynecology
General Medicine
Middle Aged
Embryo transfer
medicine.anatomical_structure
Italy
Female
Cryo-bank
Adult
Infertility
Fertilization in Vitro
Biology
Oocyte vitrification
Andrology
Young Adult
03 medical and health sciences
Genetics
medicine
Humans
Embryo Implantation
Sperm Injections
Intracytoplasmic
Blastocyst
Retrospective Studies
Cryopreservation
Assisted reproductive technology
Embryo Transfer
Oocyte
medicine.disease
Vitrification
Cumulative live birth
Pregnancy rate
Germ Cells
030104 developmental biology
Reproductive Medicine
Spain
Developmental Biology
Zdroj: Journal of Assisted Reproduction and Genetics
ISSN: 1573-7330
1058-0468
Popis: Purpose To evaluate the effectiveness, efficiency, and safety of a transnational gamete donation (TGD) programme based on the shipping of vitrified donor oocytes. Methods A retro-prospective observational study was conducted in the Assisted Reproductive Technology Center of the University Hospital of Florence, Italy. The study population included 622 consecutive donor oocyte cycles. A mean number of 6 vitrified oocytes per couple were shipped from two Spanish biobanks. In the receiving centre, gametes were warmed and inseminated and the subsequent embryo transfer (ET) was performed. The main outcome measurement was LBR. Secondary outcomes included oocyte survival rate, ICSI damage rate, normal fertilization, cleavage, and implantation rate (IR) in both ‘fresh’ and cryotransfer cycles. Results A total number of 3536 mature oocytes were warmed with 81.4% surviving oocytes. 2PN oocytes were 1941 with an ICSI normal fertilization rate of 70.4% and a cleavage rate of 93.4%; 857 day-3 embryos were transferred in 498 women, 63 blastocysts in 44. Couples with at least one vitrified embryo were 181 (32.3%). IR was 25.1% and 33.1% for day-3 ET and blastocyst stage respectively. Crude pregnancy rate and LBR after the first ET were 35.5% and 27% correspondingly with a conservative cumulative LBR of 34% and an optimal LBR of 51.4%. Conclusion Imported vitrified donor oocytes retain their competence and are capable of resulting in ongoing pregnancies and healthy babies in a proportion comparable to other existing systems as egg donation with vitrification/warming in the same laboratory and transnational fresh oocyte donation.
Databáze: OpenAIRE
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