Dorsal Root Ganglion Neurons Carrying a P301S Tau Mutation: A Valid In Vitro Model for Screening Drugs against Tauopathies?

Autor:	Lisette Klein, Niels Alberts, Karlijn Groen, Marek J. Konieczny, Mandy Koopman
Jazyk:	angličtina
Rok vydání:	2014
Předmět:	Genetically modified mouse Proline Journal Club Tau protein Drug Evaluation Preclinical tau Proteins In Vitro Techniques In vitro model MURINE TAU Dorsal root ganglion Microtubule Ganglia Spinal Serine medicine Animals Humans Protein secondary structure GeneralLiterature_REFERENCE(e.g. dictionaries encyclopedias glossaries) Neurons TRANSGENIC MICE biology General Neuroscience Neurodegeneration NEURODEGENERATION AGGREGATION medicine.disease PATHOLOGY medicine.anatomical_structure Mutation biology.protein ComputingMethodologies_DOCUMENTANDTEXTPROCESSING Tau mutation Neuroscience
Zdroj:	The Journal of Neuroscience, 34(14):10.1523/JNEUROSCI.0135-14.2014, 4757-4759. Oxford University Press
ISSN:	0270-6474
DOI:	10.1523/JNEUROSCI.0135-14.2014,
Popis:	The microtubule-binding protein tau is widely expressed in neurons, where it supports the assembly and stabilization of microtubules ([Fong et al., 2013][1]; [Spillantini and Goedert, 2013][2]). Under normal physiological conditions, tau lacks secondary structure and is highly soluble. However
Databáze:	OpenAIRE
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