Increased plasma urotensin-II levels are associated with diabetic retinopathy and carotid atherosclerosis in Type 2 diabetes
Autor: | Tsutomu Hirano, Toshiaki Suguro, Takuya Watanabe, Mitsuru Adachi, Akira Miyazaki, Gang Xu, Syuusuke Kodate |
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Rok vydání: | 2008 |
Předmět: |
Blood Glucose
Carotid Artery Diseases Male Vascular Endothelial Growth Factor A medicine.medical_specialty Urotensins Blood Pressure Type 2 diabetes Severity of Illness Index Nephropathy chemistry.chemical_compound Insulin resistance Diabetes mellitus Internal medicine medicine Humans Aged Ultrasonography Diabetic Retinopathy business.industry General Medicine Diabetic retinopathy Middle Aged medicine.disease Vascular endothelial growth factor Endocrinology Blood pressure Diabetes Mellitus Type 2 chemistry Female Epidemiologic Methods business Biomarkers Diabetic Angiopathies Retinopathy |
Zdroj: | Clinical Science. 115:327-334 |
ISSN: | 1470-8736 0143-5221 |
Popis: | Human U-II (urotensin-II), the most potent vasoconstrictor peptide identified to date, is associated with cardiovascular disease. A single nucleotide polymorphism (S89N) in the gene encoding U-II (UTS2) is associated with the onset of Type 2 diabetes and insulin resistance in the Japanese population. In the present study, we have demonstrated a relationship between plasma U-II levels and the progression of diabetic retinopathy and vascular complications in patients with Type 2 diabetes. Eye fundus, IMT (intima-media thickness) and plaque score in the carotid artery, BP (blood pressure), FPG (fasting plasma glucose), HbA1c (glycated haemoglobin), U-II, angiogenesis-stimulating factors, such as VEGF (vascular endothelial growth factor) and heregulin-β1, and lipid profiles were determined in 64 patients with Type 2 diabetes and 24 non-diabetic controls. FPG, HbA1c and VEGF levels were significantly higher in patients with Type 2 diabetes than in non-diabetic controls. Diabetes duration, insufficient glycaemic and BP control, plasma U-II levels, IMT, plaque score and nephropathy grade increased significantly across the subjects as follows: non-diabetic controls, patients with Type 2 diabetes without retinopathy (group N), patients with Type 2 diabetes with simple (background) retinopathy (group A) and patients with Type 2 diabetes with pre-proliferative and proliferative retinopathy (group B). The prevalence of obesity and smoking, age, low-density lipoprotein, triacylglycerols (triglycerides) and heregulin-β1 were not significantly different among the four groups. In all subjects, U-II levels were significantly positively correlated with IMT, FPG, and systolic and diastolic BP. Multiple logistic regression analysis revealed that, of the above parameters, U-II levels alone had a significantly independent association with diabetic retinopathy. In conclusion, the results of the present study provide the first evidence that increased plasma U-II levels may be associated with the progression of diabetic retinopathy and carotid atherosclerosis in patients with Type 2 diabetes. |
Databáze: | OpenAIRE |
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