| Autor: |
Brendan Fitzgerald, Keelin O'Donoghue, Noel McEntagart, John E. Gillan, Peter Kelehan, John O'Leary, Paul Downey, Jonathan Dean, Cillian F. De Gascun, John Bermingham, Fionnvola Armstrong, Attia Al Fathil, Nicola Maher, Cliona Murphy, Louise Burke |
| Rok vydání: |
2022 |
| Předmět: |
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| Zdroj: |
Archives of pathologylaboratory medicine. 146(5) |
| ISSN: |
1543-2165 |
| Popis: |
Context.— A severe third wave of COVID-19 disease affected Ireland in the first 3 months of 2021. In this wave, 1 second-trimester miscarriage and 6 stillbirths were observed in the Irish population because of placental insufficiency as a result of SARS-CoV-2 placentitis. This observation was at odds with the country's previous experience with COVID-19 disease in pregnant mothers. Objective.— To describe the clinical and pathologic features of these pregnancy losses. Design.— Retrospective review of clinical and pathologic data of cases of second-trimester miscarriage, stillbirth, or neonatal death identified by perinatal pathologists as being due to SARS-CoV-2 placentitis during the third wave of COVID-19 in Ireland. Results.— Clinical and pathologic data were available for review in 6 pregnancies. Sequencing or genotyping of the virus identified SARS-CoV-2 alpha (B.1.1.7) in all cases. Three of the 6 cases had maternal thrombocytopenia, and fetal growth restriction was not prominent, suggesting a rapidly progressive placental disease. Conclusions.— The identification of SARS-CoV-2 alpha in all these cases suggests that the emergence of the variant was associated with an increased risk of fetal death due to SARS-CoV-2 placentitis when compared with the original virus. Maternal thrombocytopenia may have potential as a clinical marker of placentitis, but other inflammatory markers need investigation. Three of the 6 women had been assessed for reduced fetal movements in hospital some days before the fetal deaths actually occurred; this could suggest that there may be a window for intervention in some cases. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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