Gastric and Duodenal Antiulcer Activity of Alkaloids: A Review
| Autor: | Jacqueline Alves Leite, Margareth de Fátima Formiga Melo Diniz, Alba Regina Monteiro Souza-Brito, Anderson Luiz Ferreira, José Maria Barbosa-Filho, Leônia Maria Batista, Heloina de Sousa Falcão, Ana de Almeida, Maria Célia de Oliveira Chaves, Marcelo Dantas de Moura, Petrônio Filgueiras de Athayde-Filho |
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| Jazyk: | angličtina |
| Rok vydání: | 2008 |
| Předmět: |
Pharmacological research
Peptic ulcer Review Pharmaceutical Science Review Pharmacology Analytical Chemistry lcsh:QD241-441 Alkaloids lcsh:Organic chemistry Drug Discovery medicine Animals heterocyclic compounds Stomach Ulcer Physical and Theoretical Chemistry chemistry.chemical_classification Peptic ulcer business.industry Organic Chemistry fungi food and beverages Anti-Ulcer Agents medicine.disease Terpenoid Amino acid chemistry Chemistry (miscellaneous) Duodenal Ulcer Models Animal Molecular Medicine Antiulcer activity business |
| Zdroj: | Molecules, Vol 13, Iss 12, Pp 3198-3223 (2008) Molecules |
| ISSN: | 1420-3049 |
| Popis: | Peptic ulcer disease is a deep gastrointestinal erosion disorder that involves the entire mucosal thickness and can even penetrate the muscular mucosa. Numerous natural products have been evaluated as therapeutics for the treatment of a variety of diseases, including this one. These products usually derive from plant and animal sources that contain active constituents such as alkaloids, flavonoids, terpenoids, tannins and others. The alkaloids are natural nitrogen-containing secondary metabolites mostly derived from amino acids and found in about 20% of plants. There has been considerable pharmacological research into the antiulcer activity of these compounds. In this work we review the literature on alkaloids with antiulcer activity, which covers about sixty-one alkaloids, fifty-five of which have activity against this disease when induced in animals. |
| Databáze: | OpenAIRE |
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