New model of progressive non-insulin-dependent diabetes mellitus in mice induced by streptozotocin
| Autor: | Akiko Nakatani, Mikio Ito, Yoichi Kondo, Atsuhiko Naruse |
|---|---|
| Rok vydání: | 1999 |
| Předmět: |
Blood Glucose
Male medicine.medical_specialty endocrine system diseases Ratón medicine.medical_treatment Population Pharmaceutical Science Streptozocin Diabetes Mellitus Experimental Mice Diabetes mellitus Internal medicine Medicine Animals education Pharmacology education.field_of_study geography Mice Inbred ICR geography.geographical_feature_category Dose-Response Relationship Drug business.industry Insulin Age Factors nutritional and metabolic diseases General Medicine Streptozotocin medicine.disease Islet Anti-Bacterial Agents Dose–response relationship medicine.anatomical_structure Endocrinology Diabetes Mellitus Type 2 business Pancreas medicine.drug |
| Zdroj: | Biologicalpharmaceutical bulletin. 22(9) |
| ISSN: | 0918-6158 |
| Popis: | This study was designed to clarify the relationship between streptozotocin (STZ) dosage (100, 150 and 200 mg/kg i.p.) and the resulting diabetogenic response in mice (8-week-old male ICR). In this experiment, we found that a single i.p. injection of 100 mg/kg STZ is able to induce progressive diabetes mellitus, in which non-fasting serum glucose levels begin to rise from 3 weeks and continue to rise throughout the experimental period until 9 weeks. The non-fasting serum insulin levels of 100 mg/kg STZ-treated mice were normal during the experimental period. In addition, the population of insulin-immunoreactive cells (beta cells) in the islets of pancreata was slightly less than in normal mice at 9 weeks. In 200 mg/kg STZ-treated mice, on the other hand, the insulin levels were below measurable values and insulin-immunoreactive cells were not observed. It is concluded from these results that the progressive diabetic mouse model induced by a single i.p. injection of 100 mg/kg STZ, unlike 200 mg/kg STZ-induced diabetes which is insulin-dependent, is non-insulin-dependent. |
| Databáze: | OpenAIRE |
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