Subclinical cardiac performance in obese and overweight women as a potential risk factor of preeclampsia
| Autor: | Paweł Rostoff, Andrzej Gackowski, Karolina Golinska-Grzybala, Jadwiga Nessler, Marcin Wiecheć, Bogdan Golinski, Ewa Konduracka, Barbara Szlósarczyk |
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| Rok vydání: | 2021 |
| Předmět: |
Adult
Cardiac output medicine.medical_specialty 030204 cardiovascular system & hematology Overweight Ultrasonography Prenatal Ventricular Function Left Preeclampsia 03 medical and health sciences 0302 clinical medicine Pre-Eclampsia Pregnancy Risk Factors Internal medicine Internal Medicine medicine Humans Arterial Pressure Obesity Prospective Studies Prospective cohort study Subclinical infection 030219 obstetrics & reproductive medicine business.industry Obstetrics and Gynecology medicine.disease Uterine Artery Quartile Echocardiography Case-Control Studies Pulsatile Flow Cardiology Gestation Female medicine.symptom business |
| Zdroj: | Pregnancy Hypertension. 23:131-135 |
| ISSN: | 2210-7789 |
| Popis: | Objectives Failure to increase cardiac output owing to suboptimal cardiac performance in obese women may contribute to placental hypoperfusion, and therefore subsequently to the abnormal placental development. The aim of this study was to evaluate the relationship between left ventricle (LV) function in overweight and obese pregnant women and parameters of blood flow in uterine arteries. Study design and main outcome measures We conducted a prospective cohort study, which included consecutive 87 women with singleton pregnancy − 56 women with normal weight and 31 overweight and obese women. During pregnancy blood pressure, echocardiography and the assessment of blood flow in uterine arteries - pulsatility index (PI) and resistance index (RI) were assessed on two visits (V): V1 between 10 and 14 weeks and V2 between 25 and 30 weeks of gestation. A stepwise logistic regression analysis was performed to determine the independent predictors of upper quartile of RI and PI during V2 in the study population. Results The multivariate logistic regression analysis showed that LVCI and LV mass measured on V1 were the only independent predictors of upper quartile of RI during V2, whereas LVCI was the only independent predictor of upper quartile of PI during V2. Conclusions Subclinical left ventricle dysfunction in obese and overweight women, present from the first trimester, may contribute to placental hypoperfusion and higher resistance in uterine arteries later during pregnancy. This may lead in some women to preeclampsia. |
| Databáze: | OpenAIRE |
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