Increase of Dermatan Sulfate in a Case of Pulmonary Fibrosis
| Autor: | Kiyoshi Konno, Hideo Arai, Atsunobu Yokosawa, Hiromi Nagai, Masakichi Motomiya, Hirosi Sato |
|---|---|
| Rok vydání: | 1975 |
| Předmět: |
Pulmonary Fibrosis
Proteolysis Dermatan Sulfate Cetylpyridinium chloride General Biochemistry Genetics and Molecular Biology Dermatan sulfate Glycosaminoglycan chemistry.chemical_compound Pulmonary fibrosis Hyaluronic acid medicine Humans Hyaluronic Acid Lung Glycosaminoglycans medicine.diagnostic_test Organ Size General Medicine Heparan sulfate respiratory system medicine.disease carbohydrates (lipids) medicine.anatomical_structure chemistry Biochemistry Chondroitin |
| Zdroj: | The Tohoku Journal of Experimental Medicine. 115:361-365 |
| ISSN: | 1349-3329 0040-8727 |
| Popis: | The quantity and composition of acid glycosaminoglycans (mucopolysaccharides) were compared between a fibrotic lung and normal lungs. The acid glycosaminoglycans were isolated by proteolysis, fractionation with ethanol and precipitation with cetylpyridinium chloride, and were identified by chromatography, electrophoresis and incubation with mucopoly-saccharide-lyases. Evidence was obtained for the presence of hyaluronic acid, chondroitin sulfate A(C), dermatan sulfate and heparan sulfate. Quantitation of individual glycosaminoglycans by using specific mucopolysaccharide-lyases revealed that the quantity of dermatan sulfate in the fibrotic lung exceeded that in the normal lungs. |
| Databáze: | OpenAIRE |
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