The effect of tamoxifen therapy on the endometrium and ovarian cyst formation in patients with breast cancer
| Autor: | Kyu Sup Lee, Seul Kee Lee, Ki Hyung Kim, Jong Kil Joo, Dong Suh Seo, Seungchul Kim, Yun Hwa Kim |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty lcsh:Gynecology and obstetrics 03 medical and health sciences 0302 clinical medicine Breast cancer Endometrial Polyp breast neoplasms Medicine endometrium skin and connective tissue diseases lcsh:RG1-991 Gynecology Ovarian cyst medicine.diagnostic_test tamoxifen business.industry Endometrial cancer Obstetrics and Gynecology medicine.disease Gynecological Examination Endometrial hyperplasia 030104 developmental biology 030220 oncology & carcinogenesis ovary business Tamoxifen Endometrial biopsy medicine.drug |
| Zdroj: | Obstetrics & Gynecology Science, Vol 61, Iss 5, Pp 615-620 (2018) |
| ISSN: | 2287-8580 2287-8572 |
| Popis: | Objective To evaluate the effect of tamoxifen on female reproductive organs in women with breast cancer. Methods We retrospectively reviewed the medical records of 309 women with breast cancer who were currently receiving tamoxifen and undergoing regular gynecological examination. Results We evaluated 92 pre- and 217 postmenopausal women. The prevalence of endometrial thickening was 12% in the pre- and 10.6% in the postmenopausal group. An endometrial biopsy was performed in 43 women and confirmed endometrial cancer in 1, endometrial polyps in 14, and endometrial hyperplasia in 4 women. Transvaginal ultrasonography showed 25 cases of newly developed ovarian cysts. Most ovarian cysts had disappeared during follow-up. Conclusion Tamoxifen use in women with breast cancer causes few complications and is considered safe for female reproductive organs in case of regular gynecological examination. |
| Databáze: | OpenAIRE |
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