Anti-Inflammatory and Anti-Tumor-Promoting Effects of 5-Deprenyllupulonol C and Other Compounds from Hop (Humulus lupulus L.)
| Autor: | Nobutaka Suzuki, Hideki Kohno, Hiroyuki Akazawa, Harukuni Tokuda, Aranya Manosroi, Toshihiro Akihisa, Yumiko Kimura, Jiradej Manosroi, Ken Yasukawa |
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| Rok vydání: | 2012 |
| Předmět: |
Magnetic Resonance Spectroscopy
Skin Neoplasms Humulus lupulus medicine.drug_class 9 10-Dimethyl-1 2-benzanthracene Phloroglucinol Anti-Inflammatory Agents Molecular Conformation DMBA Bioengineering Pharmacology Skin Diseases Biochemistry Anti-inflammatory Hop (networking) Mice chemistry.chemical_compound In vivo medicine Animals Anticarcinogenic Agents Edema Humulus Antigens Viral Molecular Biology chemistry.chemical_classification biology Chemistry Glycoside General Chemistry General Medicine biology.organism_classification Raji cell Carcinogens Tetradecanoylphorbol Acetate Molecular Medicine Female |
| Zdroj: | Chemistry & Biodiversity. 9:1045-1054 |
| ISSN: | 1612-1872 |
| DOI: | 10.1002/cbdv.201100233 |
| Popis: | A new phloroglucinol derivative, 5-deprenyllupulonol C (1), along with four other phloroglucinol derivatives, 2-5, five chalcones, 6-10, four flavanones, 11-14, two flavonol glycosides, 15 and 16, and five triterpenoids, 17-21, were isolated from the female inflorescence pellet extracts of hop (Humulus lupulus L.). Upon evaluation of these compounds against the Epstein-Barr virus early antigen (EBV-EA) activation induced by 12-O-tetradecanoylphorbol 13-acetate (TPA) in Raji cells, twelve compounds, i.e., 1-4, 11-14, 17-19, and 21, showed potent inhibitory effects on EBV-EA induction, with IC₅₀ values in the range of 215-393 mol ratio/32 pmol TPA. In addition, eleven compounds, i.e., 1-4, 6, 11, 12, 14, 17, 18, and 20, were found to inhibit TPA-induced inflammation (1 μg/ear) in mice, with ID₅₀ values in the range of 0.13-1.06 μmol per ear. Further, lupulone C (2) and 6-prenylnaringenin (14) exhibited inhibitory effects on skin-tumor promotion in an in vivo two-stage mouse-skin carcinogenesis test based on 7,12-dimethylbenz[a]anthracene (DMBA) as initiator and with TPA as promoter. |
| Databáze: | OpenAIRE |
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