Chronic Hemolysis May Adversely Affect Skeletal Health. A Cross-Sectional Study of a Pediatric Population
| Autor: | Artemis Doulgeraki, Vasiliki Schiza, Kalliopi Drakaki, Jacqueline Yousef, Helen Athanasopoulou, Christine Fragodimitri, Fotis Karabatsos, Ioannis Monopolis, Antonia Chatziliami |
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| Rok vydání: | 2021 |
| Předmět: |
Ineffective erythropoiesis
Male Cross-sectional study Thalassemia Clinical Biochemistry Spherocytosis Physiology medicine.disease_cause Affect (psychology) Hemolysis 03 medical and health sciences 0302 clinical medicine Absorptiometry Photon Bone Density medicine Humans Child Genetics (clinical) Lumbar Vertebrae business.industry Biochemistry (medical) beta-Thalassemia Hematology medicine.disease Skeleton (computer programming) Cross-Sectional Studies 030220 oncology & carcinogenesis Female business 030215 immunology Pediatric population |
| Zdroj: | Hemoglobin. 45(1) |
| ISSN: | 1532-432X |
| Popis: | Hereditary hemolytic disorders cause ineffective erythropoiesis and bone marrow hyperplasia. Little is known about their effect on growth and skeletal health. The aim of this study was to evaluate growth, bone and body composition of non transfusion-dependent (NTD) pediatric patients with chronic hemolysis. A detailed history and clinical examination, dual-energy X-ray absorptiometry (DXA) of the lumbar spine (LS) and total body less head (TBLH) and bone turnover markers were performed. Thirty-nine patients (22 males and 17 females, 20 prepubertal), aged 11.4 ± 3.6 years [14 had β-thalassemia intermedia (β-TI), 17 α-thalassemia (α-thal) and eight hereditary spherocytosis (HS)] were evaluated. Fifty-seven previously studied controls were used for statistical analysis. The patients had lower weight and body mass index (BMI) (Z-scores -0.2 and -0.3, respectively |
| Databáze: | OpenAIRE |
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