De-escalation therapy rates are significantly higher by bronchoalveolar lavage than by tracheal aspirate
| Autor: | Eleni Efraimidou, Konstantinos J Manolas, Elpis Giantsou, Eleonora Alepopoulou, Maria Panopoulou, Nikolaos Liratzopoulos, Sofia Kartali-Ktenidou |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2007 |
| Předmět: |
Male
medicine.medical_specialty Resuscitation Critical Care Original Critical Care and Intensive Care Medicine law.invention law Intensive care Anesthesiology De-escalation therapy medicine Ventilator-associated pneumonia Humans Prospective Studies Prospective cohort study Aged medicine.diagnostic_test Greece business.industry Pneumonia Ventilator-Associated Length of Stay Middle Aged medicine.disease Intensive care unit Surgery Anti-Bacterial Agents Trachea Pneumonia Intensive Care Units Bronchoalveolar lavage Anesthesia Female business Bronchoalveolar Lavage Fluid |
| Zdroj: | Intensive Care Medicine |
| ISSN: | 1432-1238 0342-4642 |
| Popis: | Objective To assess outcomes with de-escalation therapy in ventilator-associated pneumonia (VAP). Design Prospective observational study. Setting Multidisciplinary intensive care unit. Patients and participants VAP was diagnosed by positive quantitative cultures of both tracheal aspirate and bronchoalveolar lavage (BAL) and treated appropriately for all significant isolates of tracheal aspirate and BAL in 143 patients who were assigned to de-escalation therapy by BAL or tracheal aspirate. Interventions None. Measurements and results Antibiotic therapy was de-escalated in 58 patients (40.5%), who had decreased mortality at day 15 (5.1% vs. 31.7%) and day 28 (12% vs. 43.5%) and shorter intensive care unit (17.2 ± 1.2 vs. 22.7 ± 6.3 days) and hospital (23.7 ± 2.8 vs. 29.8 ± 11.1 days) stay (p |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink