Benign Lymphoepithelial Parotid Lesions in Vertically HIV-Infected Patients
| Autor: | Antonio Di Biagio, F. Pretolesi, Valerio Del Bono, Claudio Viscoli, Sara Tita Farinella, Michele Buscaglia, Lorenzo E. Derchi, Sara Ferrando, Matteo Bassetti, Raffaella Rosso |
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| Rok vydání: | 2006 |
| Předmět: |
Male
medicine.medical_specialty Pathology Adolescent Lymphoid Tissue Human immunodeficiency virus (HIV) HIV Infections medicine.disease_cause Gastroenterology Internal medicine medicine Humans Parotid Gland Hiv infected patients Child Parotid gland enlargement business.industry Public Health Environmental and Occupational Health Infant Ultrasonography Doppler Antiretroviral therapy Disease control Infectious Disease Transmission Vertical Cell Transformation Neoplastic Infectious Diseases Italy Child Preschool Cohort Female Parotid Diseases Ultrasonography business Follow-Up Studies |
| Zdroj: | AIDS Patient Care and STDs. 20:536-541 |
| ISSN: | 1557-7449 1087-2914 |
| Popis: | Benign lymphoepithelial parotid lesions (BLL) are frequently reported in HIV-infected patients, although their clinical and prognostic significance in HIV infection has not been clearly defined. Ultrasonography (USG) has been shown to be a reliable method in monitoring the progression of such lesions. The purpose of this study was to describe the spectrum of sonographic and Doppler findings and to monitor any clinically evident physical change of parotid glands in a cohort of congenitally HIV-infected patients taking antiretroviral therapy. USG findings-based on their severity-have been grouped in three different patterns (0, 1, 2). Our cohort consisted of 51 patients with HIV in various Centers for Disease Control (CDC) stages and being given different antiretroviral protocols. The median USG follow-up was 36 months. The most frequent USG pattern was aspecific parotid gland enlargement (type 0, 45,1%). Patients with either lower CD4+ % (p0.20) and higher absolute and percent CD8+ cell count (p0.001 and p0.003) presented more frequently a type 2 USG pattern. None of them had any symptoms ascribed to "sicca syndrome" and only one patient developed non-Hodgkin's lymphoma during the follow-up, although his USG pattern at baseline was type 0. In summary, the spectrum of USG findings of BLL in vertically HIV-infected patients is broad. Because of the reported, although rare, possible malignant transformation of BLL in HIV-infected children, it is advisable to perform-even in asymptomatic patients-USG at least once per year or in concomitance with any physical modification of the parotid lesions. |
| Databáze: | OpenAIRE |
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