Frailty syndrome and the risk of vascular dementia: The Italian Longitudinal Study on Aging
| Autor: | Solfrizzi V, Scafato E, Frisardi V, Seripa D, Logroscino G, Maggi S, Imbimbo BP, Galluzzo L, Baldereschi M, Gandin C, Di Carlo A, Inzitari D, Crepaldi G, Pilotto A, Panza F, Farchi G, Capurso A, Lepore V, Livrea P, Motta L, Carnazzo G, Motta M, Bentivegna P, Bonaiuto S, Cruciani G, Postacchini D, Amaducci L, Gandolfo C, Conti M, Franceschi M, Scarlato G, Candelise L, Scapini E, Rengo F, ABETE, PASQUALE, Cacciatore F, Enzi G, Battistin L, Sergi G, Minicucci N, Noale M, Grigoletto F, Perissinotto E, Carbonin P. |
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| Přispěvatelé: | Solfrizzi, V, Scafato, E, Frisardi, V, Seripa, D, Logroscino, G, Maggi, S, Imbimbo, Bp, Galluzzo, L, Baldereschi, M, Gandin, C, Di Carlo, A, Inzitari, D, Crepaldi, G, Pilotto, A, Panza, F, Farchi, G, Capurso, A, Lepore, V, Livrea, P, Motta, L, Carnazzo, G, Motta, M, Bentivegna, P, Bonaiuto, S, Cruciani, G, Postacchini, D, Amaducci, L, Gandolfo, C, Conti, M, Franceschi, M, Scarlato, G, Candelise, L, Scapini, E, Rengo, F, Abete, Pasquale, Cacciatore, F, Enzi, G, Battistin, L, Sergi, G, Minicucci, N, Noale, M, Grigoletto, F, Perissinotto, E, Carbonin, P. |
| Rok vydání: | 2012 |
| Předmět: |
Male
Gerontology Aging Longitudinal study medicine.medical_specialty Epidemiology Alzheimer's disease Cerebrovascular disease Cognition Dementia Frailty Vascular dementia Aged Aged 80 and over Dementia Vascular Female Humans Incidence Italy Syndrome Frail Elderly Frailty syndrome Cellular and Molecular Neuroscience Developmental Neuroscience Vascular 80 and over medicine Risk factor Proportional hazards model business.industry Health Policy Hazard ratio medicine.disease Confidence interval Surgery Psychiatry and Mental health Neurology (clinical) Geriatrics and Gerontology business |
| Zdroj: | Alzheimer's & Dementia. 9:113-122 |
| ISSN: | 1552-5279 1552-5260 |
| Popis: | Background Frailty is a clinical syndrome generally associated with a greater risk for adverse outcomes such as falls, disability, institutionalization, and death. Cognition and dementia have already been considered as components of frailty, but the role of frailty as a possible determinant of dementia, Alzheimer's disease (AD), and vascular dementia (VaD) has been poorly investigated. We estimated the predictive role of frailty syndrome on incident dementia and its subtypes in a nondemented, Italian, older population. Methods We evaluated 2581 individuals recruited from the Italian Longitudinal Study on Aging sample population consisting of 5632 subjects aged 65 to 84 years and with a 3.9-year median follow-up. A phenotype of frailty according to a modified measurement of Cardiovascular Health Study criteria was operationalized. Dementia, AD, and VaD were classified using current published criteria. Results Over a 3.5-year follow-up, 65 of 2581 (2.5%) older subjects, 16 among 252 frail individuals (6.3%), of which 9 were affected by VaD (3.6%), developed overall dementia. In a proportional hazards model, frailty syndrome was associated with a significantly increased risk of overall dementia (adjusted hazard ratio: 1.85; 95% confidence interval: 1.01–3.40) and, in particular, VaD (adjusted hazard ratio: 2.68; 95% confidence interval: 1.16–7.17). The risk of AD or other types of dementia did not significantly change in frail individuals in comparison with subjects without frailty syndrome. Conclusion In our large population-based sample, frailty syndrome was a short-term predictor of overall dementia and VaD. |
| Databáze: | OpenAIRE |
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