Protective potential of sulfated polysaccharides from tropical seaweeds against alkylating- and oxidizing-induced genotoxicity

Autor: Isisdoris, Rodrigues-Souza, Jacqueline Beatriz Kasmirski, Pessatti, Lucas Rafael, da Silva, Daniel, de Lima Bellan, Irisdoris Rodrigues, de Souza, Marta Margarete, Cestari, Helena Cristina Silva, de Assis, Hugo Alexandre Oliveira, Rocha, Fernanda Fogagnoli, Simas, Edvaldo, da Silva Trindade, Daniela Morais, Leme
Rok vydání: 2022
Předmět:
Zdroj: International Journal of Biological Macromolecules. 211:524-534
ISSN: 0141-8130
DOI: 10.1016/j.ijbiomac.2022.05.077
Popis: Sulfated polysaccharides (SPs) from seaweeds are potential bioactive natural compounds, but their DNA protective activity is poorly explored. This article aimed to evaluate the genotoxic/antigenotoxic potentials of a sulfated heterofucan from brown seaweed Spatoglossum schröederi (Fucan A - FA) and a sulfated galactan from green seaweed Codium isthomocladum (3G4S) using in vitro Comet assay (alkaline and oxidative versions) with HepG2 cells. The antioxidant activity of these SPs was evaluated by total antioxidant capacity, radical scavenging, metal chelating, and antioxidant enzyme activity assays. Both SPs were not genotoxic. FA and 3G4S displayed strong antigenotoxic activity against oxidizing chemical (H
Databáze: OpenAIRE
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