Carotid atherosclerosis is associated with inflammation and endothelial cell adhesion molecules in chronic haemodialysis patients
| Autor: | Dimitrios Kirmizis, Dimitrios Memmos, Michalis Kalovoulos, Anna-Maria Belechri, Aikaterini Papagianni, Andreas Vainas, Efstathios Alexopoulos |
|---|---|
| Rok vydání: | 2002 |
| Předmět: |
Adult
Carotid Artery Diseases Male medicine.medical_specialty Time Factors medicine.medical_treatment Vascular Cell Adhesion Molecule-1 Blood Pressure Gastroenterology Reference Values Renal Dialysis Risk Factors Internal medicine E-selectin medicine Humans Risk factor Survival analysis Aged Aged 80 and over Inflammation Transplantation biology Vascular disease business.industry Smoking Middle Aged medicine.disease Intercellular Adhesion Molecule-1 Survival Analysis Blood pressure Intima-media thickness Nephrology Immunology Multivariate Analysis biology.protein Kidney Failure Chronic Regression Analysis Female Hemodialysis Complication business E-Selectin Cell Adhesion Molecules Biomarkers Follow-Up Studies |
| Zdroj: | Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association. 18(1) |
| ISSN: | 0931-0509 |
| Popis: | Background. Recently emerging evidence suggests that endothelial adhesion molecules may participate in atherogenesis. The aim of the present report was to investigate the probable association of circulating ICAM-1, VCAM-1 and E-selectin with atherosclerotic disease in chronic haemodialysis (HD) patients. Methods. One hundred and twelve HD patients and 50 age- and sex-matched healthy normotensive controls participated in the study. Atherosclerotic disease in both groups was assessed by measuring intima– media thickness (IMT) and plaque score of the common carotid arteries using an ultrasound scanner. In addition, in a follow-up study, the survival of 81 patients after a mean period of 26 months was analysed in relation to ICAM-1 and VCAM-1 levels. Results. IMT and plaque score were significantly higher in HD patients compared with control subjects (P-0.001 and P-0.0001, respectively). The above ultrasonographic indices were correlated with age both in controls (Ps0.0001 and Ps0.002, respectively) and HD patients (Ps0.0001 and Ps0.0001, respectively). A significant relationship was observed between IMT and systolic blood pressure (BP) both in controls and in HD patients (Ps0.002 and Ps0.01, respectively). In HD patients, plaque score was also correlated with systolic BP (Ps0.02). In HD patients, IMT and plaque score were correlated significantly with log CRP values (Ps0.01 and Ps0.01, respectively). Multivariate analysis showed that log CRP values were a strong independent contributor to plaque score (Ps0.01). IMT was significantly correlated with ICAM-1 and VCAM-1 concentrations (Ps0.0001 and Ps0.003, respectively). Multivariate analysis showed that ICAM-1 concentrations were a strong independent correlate of IMT (Ps0.001). E-selectin concentrations did not show any relation with IMT or plaque score. During the follow-up period, 13 of the 81 patients died. Survival analyses showed that patients with increased ICAM-1 had a shorter survival than patients with normal ICAM-1 values and that serum ICAM-1 levels were a strong predictor of death. Conclusions. In HD patients, carotid atherosclerosis is associated with inflammation and circulating levels of soluble adhesion molecules ICAM-1 and VCAM-1. The correlations between serum ICAM-1 and IMT and ICAM-1 and survival may indicate that this molecule could be a marker of a process that contributes to the high mortality of HD patients. |
| Databáze: | OpenAIRE |
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