Late liver-related mortality from complications of transfusion-acquired hepatitis C
Autor: | Michiyasu Yagura, Hajime Tokita, Akira Ohbayashi, Hideo Tanaka, Hiroshi Kamitsukasa, Hideharu Harada |
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Rok vydání: | 2005 |
Předmět: |
Adult
Male medicine.medical_specialty Blood transfusion medicine.medical_treatment Hepacivirus Cohort Studies Liver disease Internal medicine medicine Humans Tuberculosis Aged Cause of death Aged 80 and over Hepatology business.industry Liver Diseases Transfusion Reaction Hepatitis C Hepatitis C Antibodies Middle Aged medicine.disease Survival Analysis Surgery Hepatocellular carcinoma Cohort RNA Viral Female business Follow-Up Studies Cohort study |
Zdroj: | Hepatology. 41:819-825 |
ISSN: | 1527-3350 0270-9139 |
Popis: | Although several cohort studies have been reported in individuals with chronic hepatitis C virus (HCV) infection, little is known about liver-related mortality among the elderly. We conducted a cohort study in 302 patients with tuberculosis sequelae who had received a blood transfusion at a young age and had subsequently been treated at a chest clinic. The cohort consisted of 147 patients with antibody to HCV (anti-HCV), of whom 81% were positive for HCV RNA, and 155 without anti-HCV. The cohort was followed for a mean duration of 5.7 years. There were no differences between the two groups in the mean age of the patients at the time of transfusion (31 vs. 34 years) or at the time of entry into the study (65 vs. 66 years). The outcome of 143 patients with, and 145 without, anti-HCV could be traced; 92 (64%) and 82 (57%) had died, respectively. The main cause of death was tuberculosis sequelae in 61 (42%) and 66 (46%) patients, respectively. Eight (6%) of the 143 patients with anti-HCV died of liver disease (hepatocellular carcinoma: seven; rupture of varices: one). The average annual mortality from liver disease from study entry in the patients with anti-HCV was 9.8 per 1,000 person-years. The patients with anti-HCV had a significantly lower cause-specific survival probability for liver disease (92% vs. 100% at 10 years, P < .005). In conclusion, in our study, liver-related mortality appeared to be high among elderly HCV-infected individuals. (HEPATOLOGY 2005;41:819–825.) |
Databáze: | OpenAIRE |
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