Donor-derived hepatitis C in the era of increasing intravenous drug use: A report of the Disease Transmission Advisory Committee

Autor:	Marian G. Michaels, Cameron R. Wolfe, Ajit P. Limaye, Daniel R. Kaul, Susan M. Tlusty
Rok vydání:	2018
Předmět:	medicine.medical_specialty Tissue and Organ Procurement Advisory committee Hepatitis C virus Advisory Committees Window period Hepacivirus 030230 surgery medicine.disease_cause Serology Donor Selection Drug Users 03 medical and health sciences 0302 clinical medicine Internal medicine Medicine Humans Substance Abuse Intravenous Transplantation Intravenous drug business.industry Transmission (medicine) Hepatitis C Organ Transplantation Viral Load medicine.disease Prognosis Tissue Donors 030211 gastroenterology & hepatology business Disease transmission
Zdroj:	Clinical transplantation. 32(10)
ISSN:	1399-0012
Popis:	The opioid epidemic has resulted in a potential increase in donors in the testing window period for hepatitis C virus (HCV). We analyzed HCV reports to the Disease Transmission Advisory Committee (DTAC) between 2008 and 2016 to estimate the risk of HCV transmission. In 15 of 95 (16%) reports, at least one recipient developed proven/probable donor-derived HCV resulting in 32 infected recipients. Seven transmissions occurred during the nucleic acid testing (NAT) window period; four occurred during serological window period. The other four transmission occurred due to human error (3) and false-negative serology (1). All seronegative-exposed liver and lung recipients contracted HCV; 18/21 (86%) kidney and 3/4 (75%) heart recipients developed HCV. Four transmitting donors died of intravenous drug overdose, three in 2016 and one in 2012. Among donors with a history of intravenous drug use (IVDU), drug intoxication as a mechanism of death, or increased risk status, and negative screening HCV testing, the risk of transmission to a recipient was about 1 in 1000. The overall risk of transmitting HCV from NAT-negative donors with IVDU is low and consistent with modeling data. This information may be helpful to clinicians counseling potential recipients offered these organs.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad1e8963e5647b48634e3fa61d4a929d https://pubmed.ncbi.nlm.nih.gov/30080289 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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