T2 and T2* mapping in patients after matrix-associated autologous chondrocyte transplantation: initial results on clinical use with 3.0-Tesla MRI
| Autor: | Timothy R. Hughes, Tallal C. Mamisch, Siegfried Trattnig, Goetz H. Welsch, Stefan Marlovits, Alexander Olk, S. Quirbach, M. Blanke |
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| Rok vydání: | 2009 |
| Předmět: |
musculoskeletal diseases
Adult Male medicine.medical_specialty T2 mapping Treatment outcome Sensitivity and Specificity Chondrocyte Chondrocytes medicine Humans Radiology Nuclear Medicine and imaging In patient Cartilage repair Neuroradiology medicine.diagnostic_test business.industry Reproducibility of Results Interventional radiology General Medicine Middle Aged Prognosis Magnetic Resonance Imaging Transplantation Treatment Outcome medicine.anatomical_structure Female Radiology business Cartilage Diseases |
| Zdroj: | Welsch, GH; Trattnig, S; Hughes, T; Quirbach, S; Olk, A; Blanke, M; Marlovits, S; Mamisch, TC (2010). T2 and T2* mapping in patients after matrix-associated autologous chondrocyte transplantation: initial results on clinical use with 3.0-Tesla MRI. European radiology, 20(6), pp. 1515-23. Berlin: Springer 10.1007/s00330-009-1669-y |
| ISSN: | 1432-1084 0938-7994 |
| Popis: | To use T2 and T2* mapping in patients after matrix-associated autologous chondrocyte transplantation (MACT) of the knee, and to compare and correlate both methodologies.3.0-Tesla MRI was performed on 30 patients (34.6 +/- 9.9 years) with a follow-up period of 28.1 +/- 18.8 months after MACT. Multi-echo, spin-echo-based T2 mapping using six echoes and gradient-echo-based T2* mapping using six echoes were prepared. T2 and T2* maps were obtained using a pixel-wise, mono-exponential, non-negative least-squares fit analysis. Region-of-interest analysis was performed for mean (full-thickness) as well as deep and superficial aspects of the cartilage repair tissue and control cartilage sites.Mean T2 values (ms) were comparable for the control cartilage (53.4 +/- 11.7) and the repair tissue (55.5 +/- 11.6) (p0.05). Mean T2* values (ms) for control cartilage (30.9 +/- 6.6) were significantly higher than those of the repair tissue (24.5 +/- 8.1) (p0.001). Zonal stratification was more pronounced for T2* than for T2. The correlation between T2 and T2* was highly significant (p0.001), with a Pearson coefficient between 0.276 and 0.433.T2 and T2* relaxation time measurements in the evaluation of cartilage repair tissue and its zonal variation show promising results, although the properties visualised by T2 and T2* may differ. |
| Databáze: | OpenAIRE |
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