Determinants of second-order bile duct visualization at CT cholangiography in potential living liver donors

Autor: Alexander W. Keedy, Fergus V. Coakley, John P. Roberts, Richard S. Breiman, Benjamin M. Yeh, Emily M. Webb
Rok vydání: 2013
Předmět:
Adult
Male
medicine.medical_specialty
bile duct visualization
Adolescent
Clinical Sciences
Gastroenterology
Sensitivity and Specificity
Article
chemistry.chemical_compound
Iodipamide Meglumine
Cholangiography
Clinical Research
Internal medicine
Preoperative Care
Living Donors
Medicine
Humans
Radiology
Nuclear Medicine and imaging
Tomography
Retrospective Studies
Creatinine
medicine.diagnostic_test
business.industry
Bile duct
Patient Selection
Liver Disease
Reproducibility of Results
Mean age
General Medicine
liver donor
Middle Aged
X-Ray Computed
Liver Transplantation
Nuclear Medicine & Medical Imaging
medicine.anatomical_structure
chemistry
Liver donors
Alkaline phosphatase
Biomedical Imaging
Female
Bile Ducts
business
Tomography
X-Ray Computed
Digestive Diseases
Body mass index
CT cholangiography
Zdroj: AJR. American journal of roentgenology, vol 200, iss 5
Popis: ObjectiveThe purpose of this article is to investigate the determinants of second-order bile duct visualization at CT cholangiography in living potential liver donors.Materials and methodsWe retrospectively identified 143 potential living liver donors (83 men and 60 women; mean age, 37 years) evaluated with CT cholangiography, which included a slow infusion of iodipamide meglumine with CT acquisition 15 minutes after biliary contrast agent administration. Two readers independently scored the visualization of the second-order bile duct branches on a previously established 4-point scale (0 = not seen, 1 = faintly seen, 2 = well seen, and 3 = excellent visualization). Multivariate analysis was used to investigate the correlation between visualization scores and potential determinants of second-order bile duct opacification, specifically age, body mass index, creatinine level, total and direct bilirubin levels, alkaline phosphatase level, aspartate aminotransferase level, alanine aminotransferase level, patient maximum linear width, CT noise, and hepatosplenic attenuation difference at unenhanced CT.ResultsThe mean (± SD) second-order bile duct visualization scores were 2.35 ± 0.66 and 2.55 ± 0.60 for readers 1 and 2, respectively. In the multivariate analysis, the only independent predictors of reduced second-order bile duct visualization were higher alkaline phosphatase level (p = 0.01) and higher CT noise (p = 0.02).ConclusionHigher serum alkaline phosphatase level and higher CT noise in potential living liver donors indicate a higher risk of poor second-order bile duct visualization at CT cholangiography.
Databáze: OpenAIRE
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